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Current Research: The major subject of research in the lab deals with Vascular Targeted Photodynamic Therapy (VTP). This novel anti cancer treatment modality was developed in the last 15 years in collaboration with Professor Avigdor Scherz from the Department of Plant Sciences at the Weizmann. The treatment comprises of i.v infusion of Pd-bacteriochlorophyll based photosensitzers synthesized in the A. Scherz laboratory with concomitant illumination (760nm) of the target tumor for 15-20 minutes via interstitial optic-fibers. The cytotoxic superoxide & hydroxyl radicals locally generated, induce vacular damage (blood cloting and vasoconstriction) that block blood supply to the tumor within minutes, leading to focal tumor ablation within days and to healing within weeks. Only a single treatment session is required and drug clearance from the circulation is completed within minutes, circumventing patient's skin photo-toxicity. In preclinical studies we showed that the success rates of VTP in mice and rats are high (50-90%) and in case of failure a 2nd treatment can be delivered with increased success rate. Tumor response and healing are associated with extensive immune response and with development of tumor resistance that may be applied in future long term therapy. Magnetic resonance imaging (MRI), based on photochemical generation of in-situ paramagnetic deoxyhemoglobin contrast was developed for online follow up of VTP progress. Clinical trials for therapy of prostate cancer and age related macular degeneration in collaboration with Steba Biotech are in progress.
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