Research
Neuronal circuit formation
Normal brain function relies on proper formation of neural networks during embryonic development. The establishment of neuronal circuitry during development requires the proper guidance and targeting of growing axons, the proper organization of axonal and dendritic arbors at the target region, and the appropriate synaptic formation. My lab have chosen the powerful genetic model system Drosophila melanogaster to study the molecular mechanisms controlling neuronal circuit formation, which led to the identification of a number of important and evolutionarily conserved genes. We are currently taking a combination of biochemical, molecular and genetic approaches to understand the exact mechanisms by which these genes regulate neuronal circuit formation during development. These studies are not only essential for understanding the fundamental biology of neuronal hardwiring during brain development, but also provide invaluable clues for the development of new therapeutic strategies aiming to regenerate functional circuits after nerve injuries in patients.