RESEARCH INTERESTS
Increasing evidence indicates that further exploration of cellular quality control system is critical for understanding the basic mechanism underlying neurodegenerative disorders including amyotrophic lateral sclerosis, Parkinson’s disease and Alzheimer’s disease. The goal of our studies is to describe how protein, organelle and membrane-less organelle quality control systems, including ubiquitin-proteasome system, autophagy and biomolecular phase separation machinery, fail to protect neurons at disease stages. To this end, we will use cell biology, molecular biology, biochemical approaches and genetic manipulation of animal models to investigate the relationship between these quality control systems and neurodegeneration.