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The ultimate goal of the Ye research group is to understand how cells deal with misfolded proteins in the endoplasmic reticulum (ER), the major site of protein biosynthesis in cells, and other cellular compartments. Protein quality control is an extremely important cellular function required for the fitness of a multicellular organism. Accordingly, defects in protein quality control are associated with increased protein misfolding, a trait closely linked to human disease conditions. The lab wishes to use cell-free systems to understand how precisely the retrotranslocation machinery works. It also wants to understand the precise mechanisms that permit many ER-associated degradation (ERAD) machinery proteins, which are involved in quality control, such as p97 and Bag6, to act in a concerted manner to eliminate misfolded proteins.
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论文共 9 篇作者统计合作学者相似作者
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Lihui Wang, Yue Xu,Tetsunari Fukushige,Layla Saidi, Xiaorong Wang,Clinton Yu,Jin-Gu Lee, Michael Krause,Lan Huang,Yihong Ye
Lenka Schorova,Nathalie Bedard,Anouar Khayachi, Hung-Hsiang Ho, Joao Bolivar-Pedroso,Julie Huynh, Mikaela Piccirelli,Yifei Wang, Marie Plourde,Wen Luo,Esther del Cid-Pellitero,Irina Shlaifer,
NPJ PARKINSONS DISEASEno. 1 (2023)
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