Yehuda Shoenfeld works at Sheba Medical Center in Tel HaShomer and the Sackler Faculty of Medicine at Tel-Aviv University. He studied at the Hebrew University of Jerusalem. He is the incumbent of the Laura Schwarz-Kipp Chair for Research of Autoimmune Diseases. Shoenfeld is the editor of two journals, Harefuah (Medicine) in Hebrew with English abstracts and Israel Medical Association Journal (IMAJ). He is co-editor-in-chief of Autoimmunity Reviews, and co-editor of the Journal of Autoimmunity,[3] and member of the editorial board of the Clinical Reviews in Allergy & Immunology.

Schoenfeld, who has been characterized as an anti-vaccinationist, proposed a syndrome he calls Autoimmune Syndrome Induced by Adjuvants (ASIA), which purports to be an autoimmune response to vaccine adjuvants. There is a lack of reproducible evidence for any causal relationship between adjuvant and autoimmune condition. He served on the scientific advisory board of the anti-vaccine group Children's Medical Safety Research Institute, has spoken at a number of antivaccination conferences, and has regularly appeared as an expert witness for people attempting to prove injury from vaccines in court.