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Research in the Daaka lab focuses on understanding the biological roles of G protein-coupled and androgen receptors that instruct embryonic development and continue to function in adulthood. He has been involved in crucial discoveries that unraveled contribution of these receptors to human pathophysiologic processes; for example, in the initiation and progression of cancer. Research from the Daaka lab on the function of these receptor systems has contributed to their recognition as targets for cancer therapy, and over the last decade several anti-cancer drugs have been developed against these molecules. Current projects examine contribution of the G protein-coupled receptors and their heterotrimeric G proteins and Arrestin effectors to the progression of prostate cancer from androgen-dependent to castration-resistant state, and in the metastasis of kidney cancer. We are also studying post-translational modification of androgen receptor by S-nitrosylation and its role in progression of the disease. Another area of investigation in the Daaka lab is centered on studying mechanisms involved in vesicle trafficking in recurrent urinary tract infections, with emphasis on the G proteins dynamin that support fission of vesicles from the plasma membrane into the cytosol.
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Prabir Kumar Chakraborty,Yushan Zhang, Alexandra S. Coomes,Wan-Ju Kim,Rachel Stupay, Lauren D. Lynch, Tamieka Atkinson,Jae I. Kim,Zhongzhen Nie,Yehia Daaka
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Prabir Kumar Chakraborty,Yushan Zhang, Alexandra S. Coomes,Wan-Ju Kim,Rachel Stupay, Lauren D. Lynch, Tamieka Atkinson,Jae I. Kim,Zhongzhen Nie,Yehia Daaka
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Iqbal Mahmud,Guimei Tian,Jia Wang,Tarun E. Hutchinson, Brandon J. Kim,Nikee Awasthee,Seth Hale,Chengcheng Meng, Allison Moore,Liming Zhao,Jessica E. Lewis,Aaron Waddell,
Nature communicationsno. 1 (2023): 1927-20
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