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个人简介
Dr. Bai’s group is interested in understanding the basic principles that control the dynamic folding/unfolding processes of protein and chromatin using biophysical approaches. The failure of proteins to properly fold can impact their biological activity, while the folding and compaction of DNA are critical for the regulation of gene expression and cell function. Defects in either of these processes can contribute to the development of many diseases, including cancer. Thus, an understanding of their folding mechanisms is critical for the advancement of cancer research, and for the discovery of potential treatment options. Dr. Bai pioneered the native-state hydrogen exchange approach for revealing partially unfolded states of proteins. The recent studies in his group have focused on chromatin structure and dynamics using methyl-based NMR and Cryo-EM methods, which have resulted in structural insights into several important proteins in complex with the nucleosome.
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NUCLEIC ACIDS RESEARCHno. 4 (2024): 1688-1701
bioRxiv (Cold Spring Harbor Laboratory) (2024)
bioRxiv : the preprint server for biology (2024)
Dustin C. Becht,Brianna J. Klein,Akinori Kanai,Suk Min Jang,Khan L. Cox,Bing-Rui Zhou,Sabrina K. Phanor,Yi Zhang, Ruo-Wen Chen,Christopher C. Ebmeier,Catherine Lachance,Maxime Galloy,
bioRxiv (Cold Spring Harbor Laboratory) (2023)
bioRxiv (Cold Spring Harbor Laboratory) (2023)
SSRN Electronic Journal (2022)
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