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The major goal of our research program is to determine the molecular mechanisms by which oxygen sensing transcription factors regulate gastrointestinal homeostasis, inflammation and cancer. Cellular oxygen level is an important systemic signal that modulates metabolic activities and disease in the liver and intestine. Low cellular oxygen also referred to as hypoxia is observed in several gastrointestinal diseases such as non-alcoholic and alcoholic fatty liver disease, inflammatory bowel disease and liver and colon cancers. Regulation of hypoxia-mediated genes is dependent on the nuclear transcription factor, hypoxia inducible factor (HIF). HIF signaling is critical in the adaptive response to low oxygen levels by activating genes involved in metabolism, angiogenesis, cell survival and iron metabolism. Using the latest in mouse transgenic technology we have developed novel animal models to study accurately the role of oxygen sensitive transcription factors in the liver and intestine. These studies have revealed new pathways that have not previously been associated with hypoxia.
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ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASEno. 1 (2024): 291-317
Wesley Huang,Nupur K Das, Megan D Radyk,Theresa Keeley,Miguel Quiros,Chesta Jain,Marwa O El-Derany, Thaarini Swaminathan, Sofia Dziechciarz,Joel K Greenson,Asma Nusrat,Linda C Samuelson,
The Journal of nutrition (2024)
Shannon E. McCollum,Yatrik M. Shah
Yingying Yu, Yunxing Su,Sisi Yang, Yutong Liu, Zhiting Lin,Nupur K Das,Qian Wu, Jiahui Zhou,Shumin Sun,Xiaopeng Li, Wuyang Yue,Yatrik M Shah,
Advanced science (Weinheim, Baden-Wurttemberg, Germany)no. 12 (2024): e2307022-e2307022
Megan L Schaller, Madeline L Sykes, Joy Mecano,Sumeet Solanki,Wesley Huang,Ryan J Rebernick,Safa Beydoun, Emily Wang, Amara Bugarin-Lapuz,Yatrik M Shah,Scott F Leiser
biorxiv(2024)
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGYno. 1 (2024): G53-G66
Roshan Kumar,Victor Vitvitsky, Apichaya Sethaudom,Rashi Singhal,Sumeet Solanki, Sydney Alibeckoff,Harrison L. Hiraki,Hannah N. Bell,Anthony Andren,Brendon M. Baker,Costas A. Lyssiotis,Yatrik M. Shah,
Nature Chemical Biologypp.1-11, (2024)
Yingying Yu, Yunxing Su, Sisi Yang, Yutong Liu, Zhiting Lin,Nupur K. Das,Qian Wu, Jiahui Zhou,Shumin Sun,Xiaopeng Li, Wuyang Yue,Yatrik M. Shah,
Advanced Scienceno. 12 (2024)
Ajay Bhat, Rebecca L Cox, Brice Graham Hendrickson,Nupur K Das,Megan L Schaller, Angela M Tuckowski,Emily Wang,Yatrik M Shah,Scott F Leiser
Science advancesno. 14 (2024): eadk8823-eadk8823
Yingying Yu, Yunxing Su,Sisi Yang, Yutong Liu, Zhiting Lin,Nupur K. Das,Qian Wu, Jiahui Zhou,Shumin Sun,Xiaopeng Li, Wuyang Yue,Yatrik M. Shah,
ADVANCED SCIENCE (2024)
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