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职业迁徙
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Currently, the research in my lab is following up those lines of investigation that were successfully developed over the past several years and aim at the following issues.
We will continue to investigate the roles of immediate-early proteins ORF50 and ORF45 in KSHV replication and pathogenicity. In particular, ORF45 inhibits virus-induced interferon production by blocking IRF-7 phosphorylation and nuclear translocation. This protein is not only expressed with immediate-early kinetics, but is also packaged into infectious virions. Our hypothesis is that ORF45 has crucial roles in both initial infection process and viral reactivation.
We will analyze the structure and function of KSHV ori-Lyt and investigating the role of the ori-Lyt binding proteins K8 and ORF50 in the regulation of KSHV lytic DNA replication. Furthermore, a number of cellular proteins have recently been identified in the KSHV lytic replication complex in our lab using a proteomic approach. The data suggest that the viral lytic replication requires association of an ori-Lyt with nuclear matrix and is coupled with transcription events. Thus, we will study the regulation of viral DNA replication in different levels including nuclear skeleton, chromatin structure and interplay between DNA replication and transcription.
We will continue to investigate the roles of immediate-early proteins ORF50 and ORF45 in KSHV replication and pathogenicity. In particular, ORF45 inhibits virus-induced interferon production by blocking IRF-7 phosphorylation and nuclear translocation. This protein is not only expressed with immediate-early kinetics, but is also packaged into infectious virions. Our hypothesis is that ORF45 has crucial roles in both initial infection process and viral reactivation.
We will analyze the structure and function of KSHV ori-Lyt and investigating the role of the ori-Lyt binding proteins K8 and ORF50 in the regulation of KSHV lytic DNA replication. Furthermore, a number of cellular proteins have recently been identified in the KSHV lytic replication complex in our lab using a proteomic approach. The data suggest that the viral lytic replication requires association of an ori-Lyt with nuclear matrix and is coupled with transcription events. Thus, we will study the regulation of viral DNA replication in different levels including nuclear skeleton, chromatin structure and interplay between DNA replication and transcription.
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PLOS PATHOGENSno. 1 (2024): e1011934-e1011934
Genesno. 6 (2023): 1178-1178
RNAno. 11 (2022): 1410-1411
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Hai-na Yu,Ting Jiang,Shuang Liu,Yan Yuan,Shao-yan Xi,Zhi-wei Guo, Yuan-hong Yuan,Yan Li,Wei-wei Xiao
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