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个人简介
We are interested in the specificity of translation of the genetic code, focusing on the questions of how tRNAs are synthesized, matured, modified, aminoacylated, and function on the ribosome.
The tRNA molecules are essential for the specificity of decoding, which is the key determinant in the speed and quality of cell growth. Elevated levels of tRNAs can lead to cancer, while deficiency in tRNAs can lead to cell toxicity.
To address these fundamental questions at the mechanistic level, we have developed a variety of methods, including biochemical, structural, kinetic, and genetic approaches. We focus on one representative enzyme in each case and build a framework of information by examining the enzyme in the larger biological context. Because tRNAs are ancient and enzymes that interact and recognize tRNAs are also ancient, we have a large database to search for related and homologous enzymes in evolution.
Our research provides the basis to gain biochemical, structural, and bioinformatic insights into tRNAs in evolution. These insights are important for understanding the origins of the genetic code and for developing new strategies for drug targeting against diseases arising from errors of tRNA functions.
The tRNA molecules are essential for the specificity of decoding, which is the key determinant in the speed and quality of cell growth. Elevated levels of tRNAs can lead to cancer, while deficiency in tRNAs can lead to cell toxicity.
To address these fundamental questions at the mechanistic level, we have developed a variety of methods, including biochemical, structural, kinetic, and genetic approaches. We focus on one representative enzyme in each case and build a framework of information by examining the enzyme in the larger biological context. Because tRNAs are ancient and enzymes that interact and recognize tRNAs are also ancient, we have a large database to search for related and homologous enzymes in evolution.
Our research provides the basis to gain biochemical, structural, and bioinformatic insights into tRNAs in evolution. These insights are important for understanding the origins of the genetic code and for developing new strategies for drug targeting against diseases arising from errors of tRNA functions.
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Nature Chemical Biologyno. 4 (2024): 406-407
Yuko Nakano,Howard Gamper, Henri McGuigan,Sunita Maharjan,Zhiyi Sun, Keerthana Krishnan, Erbay Yigit,Nan-Sheng Li,Joseph A Piccirilli, Ralph Kleiner, Nicole Nichols,Ya-Ming Hou
bioRxiv : the preprint server for biology (2023)
Methods in molecular biology (Clifton, N.J.) (2023): 101-106
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biorxiv(2023)
Nature communicationsno. 1 (2023): 334-12
Methods in molecular biology (Clifton, N.J.) (2023): 263-271
Sunita Maharjan,Howard Gamper, Yuka Yamaki, Robert Y Henley,Nan-Sheng Li,Takeo Suzuki,Tsutomu Suzuki,Joseph A Piccirilli,Meni Wanunu,Erin Seifert,Douglas C Wallace,Ya-Ming Hou
bioRxiv : the preprint server for biology (2023)
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