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Cell adhesion is crucial for many biological phenomena such as tissue morphogenesis, immune response and tumor invasion. The aggregations of membrane receptors on cellular interfaces during these physical processes initiate the elaborate intracellular networks of signaling pathways. Despite of remarkable experimental achievements, there is still long way to eventually form a mechanistic understanding to cell adhesion, and further decipher its intricate connection to signal transduction. By integrating computational analysis with experimental measurements, our lab focuses on developing multi-scale modeling frameworks to study the cross-talks between cell adhesion and cell signaling. We are particularly interested to ask following questions: why and how different cells form contacts; when and where these contacts are formed at specific locations of our bodies; what are their functional impacts to the downstream signaling pathways, and further to our human health.
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论文共 87 篇作者统计合作学者相似作者
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Zhixin Jing,Phillip Galbo, Luis Ovando, Megan Demouth, Skylar Welte, Rosa Park,Kartik Chandran,Yinghao Wu,Thomas MacCarthy,Deyou Zheng,David Fooksman
bioRxiv : the preprint server for biology (2024)
Jirapat Thongchol,Zihao Yu,Laith Harb,Yiruo Lin,Matthias Koch, Matthew Theodore, Utkarsh Narsaria,Joshua Shaevitz,Zemer Gitai,Yinghao Wu,Junjie Zhang,Lanying Zeng
Science (New York, N.Y.)no. 6691 (2024): eadl0635-eadl0635
BIOPHYSICAL JOURNALno. 2 (2024): 235-247
BIOPHYSICAL JOURNALno. 4 (2024): 424-434
bioRxiv (Cold Spring Harbor Laboratory) (2023)
bioRxiv : the preprint server for biology (2023)
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