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职业迁徙
个人简介
Dr. Shimizu is focused on trying to understand how immune responses are generated and how that information can be used in the clinic to improve patient care. He and his colleagues are particularly interested in identifying the general principles by which the T-cell response is initiated. These cells require contact with other cells order to become activated and play their role in an antigen-specific immune response. Cellular adhesion processes and cell-surface receptors transmit biochemical signals inside the cells that lead to T-cell activation and differentiation into cytotoxic T cells or helper T cells. Cellular adhesion spurs efficient trafficking of lymphocytes through the body and their influx to inflammatory sites. Shimizu’s laboratory is investigating the signaling pathways that regulate the strength of these adhesive interactions. His team is also exploring the functional significance of these T-cell molecular mechanisms and their role in the ability of the immune system to respond to pathogens and tumors.
研究兴趣
论文共 285 篇作者统计合作学者相似作者
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Science translational medicineno. 702 (2023): eadd1175-eadd1175
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature (2022)
biorxiv(2022)
Brandon J. Burbach,Stephen D. O’Flanagan,Qi Shao,Katharine M. Young,Joseph R. Slaughter,Meagan R. Rollins, Tami Jo L. Street, Victoria E. Granger,Lalit. K. Beura,Samira M. Azarin, Satish Ramadhyani,Bruce R. Forsyth,
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature (2020)
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature (2020)
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature (2019)
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