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个人简介
Yvonne Kapila is a clinician scientist with over 20 years of experience studying the basic mechanisms and translational and clinical aspects of periodontal disease pathogenesis and head and neck cancer carcinogenesis using in vitro and in vivo models and human clinical studies. Her early research focused on understanding the basic extracellular matrix (ECM) processes and host-microbial mechanisms that govern head and neck cancer tumorigenesis and periodontal disease pathogenesis. Kapila made important discoveries focused on the cell and molecular biology mechanisms that regulate anoikis; programmed cell death or apoptosis triggered by loss of extracellular matrix contacts. Kapila's recent research has extended to omics approaches and biomarker discovery for head and neck cancer using metabolomic and microbiome approaches. Her related work in sirtuin biology and oral cancer were seminal in showing that sirtuin 3, a metabolic enzyme, regulates and promotes oral cancer tumorigenesis. Recently funded projects in her lab have focused on host-microbial interactions and the novel role of bacteriocins in biomedical applications, including as modulators of tumorigenesis and disease-associated biofilms and the oral microbiome.
研究兴趣
论文共 116 篇作者统计合作学者相似作者
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npj Biofilms and Microbiomesno. 1 (2024): 1-23
J A Weintraub,M Kaeberlein, C Perissinotto,K A Atchison, X Chen,R N D'Souza, J S Feine, E M Ghezzi,K L Kirkwood,M Ryder, L D Slashcheva,R Touger-Decker,
Advances in dental researchno. 1 (2023): 2-15
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Chuanjiang Zhao,Ryutaro Kuraji,Changchang Ye,Li Gao,Allan Radaic,Pachiyappan Kamarajan, Yoshimasa Taketani,Yvonne L. Kapila
Journal of Neuroinflammationno. 1 (2023): 1-13
World journal of gastroenterologyno. 6 (2023): 967-996
Journal of Evidence-Based Dental Practiceno. 4 (2023): 101916-101916
Allan Radaic,Pachiyappan Kamarajan, Alex Cho, Sandy Wang, Guo-Chin Hung, Fereshteh Najarzadegan,David T. Wong,Hung Ton-That,Cun-Yu Wang,Yvonne L. Kapila
PERIODONTOLOGY 2000 (2023)
The lancet. Healthy longevityno. 11 (2022): e777-e788
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