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Xinchun Tong

Department of Medicinal Chemistry, Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065, USA

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Papers63 papers

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Discovery of orally active hepatoselective glucokinase activators for treatment of Type II Diabetes Mellitus

Jiayi Xu,Songnian Lin,Robert W Myers,Maria E Trujillo, Michele J Pachanski, Sunita Malkani, Hsuan-Shen Chen, Zhesheng Chen, Brian Campbell,George J Eiermann, Nadine Elowe, Brian T Farrer

Bioorganic & Medicinal Chemistry Letters, no. 9 (2017): 2063-2068

Cited by2WOSBibtex

Novel, highly potent systemic glucokinase activators for the treatment of Type 2 Diabetes Mellitus

Jiayi Xu,Songnian Lin,Robert W Myers, George Addona,Joel P Berger, Brian Campbell, Hsuan-Shen Chen, Zhesheng Chen,George J Eiermann, Nadine H Elowe, Brian T Farrer, Wen Feng

Bioorganic & Medicinal Chemistry Letters, no. 9 (2017): 2069-2073

Cited by3WOSBibtex

Discovery of N-[Bis(4-methoxyphenyl)methyl]-4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamide (MK-8617), an Orally Active Pan-Inhibitor of Hypoxia-Inducible Factor Prolyl Hydroxylase 1-3 (HIF PHD1-3) for the Treatment of Anemia

John S. Debenham,Christina B. Madsen-Duggan,Matthew J. Clements,Thomas F. Walsh,Jeffrey T. Kuethe,Mikhail Reibarkh,Scott P. Salowe,Lisa M. Sonatore,Richard Hajdu,James A. Milligan,Denise M. Visco, Dan Zhou

Journal of Medicinal Chemistry, no. 24 (2016): 11039-11049

Bibtex

Measurement of catecholamines in rat and mini-pig plasma and urine by liquid chromatography-tandem mass spectrometry coupled with solid phase extraction

Huaibing He,Ester Carballo-Jane,Xinchun Tong,Lucinda H Cohen

Journal of Chromatography B, (2015): 154-161

Cited by3WOSBibtex

Pharmacological inhibition of diacylglycerol acyltransferase 1 reduces body weight and modulates gut peptide release--potential insight into mechanism of action

Jinqi Liu,Judith N Gorski,Stephen J Gold,Dunlu Chen,Shirley Chen,Gail Forrest,Yoshiki Itoh,Donald J Marsh,David G McLaren,Zhu Shen,Lisa Sonatore,Ester Carballo-Jane

Obesity (Silver Spring, Md.), no. 7 (2013): 1406-1415

Cited by11WOSSCOPUSBibtex

Pharmacological inhibition of diacylglycerol acyltransferase 1 reduces body weight and modulates gut peptide release-Potential insight into mechanism of action: DGAT1 as a Key Regulator of Metabolic Pathways

Bindhu V Karanam,Junichi Sakaki,Daphne Szeto,Xinchun Tong,Jianying Xiao,Ryo Yoshimoto,Hong Yu,Thomas P Roddy,James M Balkovec,Shirly Pinto,Xiaoming Guan,Stephanie Craw

Obesity, (2013)

Bibtex

Discovery of novel, potent, selective, and orally active human glucagon receptor antagonists containing a pyrazole core

Dong-Ming Shen,Edward J Brady,Mari R Candelore,Qing Dallas-Yang,Victor D-H Ding,William P Feeney,Guoquiang Jiang,Margaret E McCann,Steve Mock,Sajjad A Qureshi,Richard Saperstein,Xiaolan Shen

Bioorganic & Medicinal Chemistry Letters, no. 1 (2011): 76-81

Cited by33WOSEIBibtex

2-Arylbenzoxazoles as CETP inhibitors: raising HDL-C in cynoCETP transgenic mice

Florida Kallashi,Dooseop Kim,Jennifer Kowalchick,You Jung Park,Julianne A Hunt,Amjad Ali,Cameron J Smith,Milton L Hammond,James V Pivnichny,Xinchun Tong,Suoyu S Xu,Matt S Anderson

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, no. 1 (2011): 558-561

Cited by21WOSEIBibtex

Biphenyl-Substituted Oxazolidinones as Cholesteryl Ester Transfer Protein Inhibitors: Modifications of the Oxazolidinone Ring Leading to the Discovery of Anacetrapib

Peter J Sinclair,Suoyu S Xu,Xinchun Tong,James V Pivnichny,Raymond Rosa,Laurence B Peterson,Melanie Latham,Annemarie Cumiskey,Samuel D Wright,Carl P Sparrow,Denise P Milot,Sheryl A Hyland

Journal of Medicinal Chemistry, (2011)

Cited by19Bibtex

Discovery of benzimidazole pyrrolidinyl amides as prolylcarboxypeptidase inhibitors

Hong C. Shen,Fa-Xiang Ding,Changyou Zhou,Yusheng Xiong,Andreas Verras,Renee M. Chabin,Suoyu Xu,Xinchun Tong,Dan Xie,Michael E. Lassman,Urmi R. Bhatt,Margarita M. Garcia-Calvo

Bioorganic & Medicinal Chemistry Letters, no. 5 (2011): 1299-1305

Cited by16EIWOSBibtex

Substituted fused bicyclic pyrrolizinones as potent, orally bioavailable hNK 1 antagonists

Gregori J Morriello,Sander G Mills, Tricia J Johnson,Mikhail Reibarkh,Gary G Chicchi,Julie A Demartino,Marc M Kurtz,Patrick T Davies,K L C Tsao,Song Zheng,Xinchun Tong,Emma Carlson

Bioorganic & Medicinal Chemistry Letters, no. 6 (2010): 2007-2012

Cited by7Bibtex

Fused tricyclic pyrrolizinones that exhibit pseudo-irreversible blockade of the NK1 receptor

Gregori J. Morriello,Gary Chicchi,Tricia Johnson,Sander G. Mills,Julie DeMartino,Marc Kurtz,K.L.C. Tsao,Song Zheng,Xinchun Tong,Emma Carlson,Karen Townson,Alan Wheeldon

Bioorganic & Medicinal Chemistry Letters, no. 19 (2010): 5925-5932

Cited by7EIWOSBibtex

Substituted fused bicyclic pyrrolizinones as potent, orally bioavailable hNK1 antagonists

Gregori J. Morriello,Sander G. Mills,Tricia Johnson,Mikhail Reibarkh,Gary Chicchi,Julie DeMartino,Marc Kurtz,P. Davies,K.L.C. Tsao,Song Zheng,Xinchun Tong,Emma Carlson

Bioorganic & Medicinal Chemistry Letters, no. 6 (2010): 2007-2012

EIWOSBibtex

Fused tricyclic pyrrolizinones that exhibit pseudo-irreversible blockade of the NK 1 receptor

Gregori J Morriello,Gary G Chicchi, Tricia J Johnson,Sander G Mills,Julie A Demartino,Marc M Kurtz,K L C Tsao,Song Zheng,Xinchun Tong,Emma Carlson,Karen Townson,Alan Wheeldon

Bioorganic & Medicinal Chemistry Letters, no. 19 (2010): 5925-5932

Bibtex

Tetrahydroindolizinone NK1 antagonists

Jianming Bao,Huagang Lu,Gregori J Morriello,Emma J Carlson,Alan Wheeldon,Gary G Chicchi,Marc M Kurtz,Kwei-Lan C Tsao,Song Zheng,Xinchun Tong,Sander G Mills,Robert J DeVita

Bioorganic & Medicinal Chemistry Letters, no. 7 (2010): 2354-2358

Cited by4WOSEIBibtex

Tetrahydroindolizinone NK 1 antagonists

Jianming Bao,Huagang Lu,Gregori J Morriello,Emma J Carlson,Alan Wheeldon,Gary G Chicchi,Marc M Kurtz,Kweilan C Tsao,Song Zheng,Xinchun Tong,Sander G Mills,Robert J Devita

Bioorganic & Medicinal Chemistry Letters, (2010)

Cited by4Bibtex

Design of a novel class of biphenyl CETP inhibitors

Zhijian Lu,Joann B Napolitano,Ashleigh Theberge,Amjad Ali,Milton L Hammond,Eugene Tan,Xinchun Tong,Suoyu S Xu,Melanie J Latham,Laurence B Peterson,Matt S Anderson,Suzanne S Eveland

Bioorganic & Medicinal Chemistry Letters, no. 24 (2010): 7469-7472

Cited by10WOSEIBibtex

Furo[2,3-b]pyridine-based cannabinoid-1 receptor inverse agonists: Synthesis and biological evaluation. Part 1

John S. Debenham,Christina B. Madsen-Duggan,Richard B. Toupence,Thomas F. Walsh,Junying Wang,Xinchun Tong,Sanjeev Kumar,Julie Lao,Tung M. Fong,Jing Chen Xiao,Cathy R.-R.C. Huang,Chun-Pyn Shen

Bioorganic & Medicinal Chemistry Letters, no. 4 (2010): 1448-1452

Cited by14EIWOSBibtex

Discovery of a biaryl cyclohexene carboxylic acid (MK-6892): a potent and selective high affinity niacin receptor full agonist with reduced flushing profiles in animals as a preclinical candidate

Hong C Shen,Fa-Xiang Ding,Subharekha Raghavan,Qiaolin Deng,Silvi Luell,Michael J Forrest,Ester Carballo-Jane,Larissa C Wilsie,Mihajlo L Krsmanovic,Andrew K Taggart,Kenneth K Wu,Tsuei-Ju Wu

Journal of medicinal chemistry, no. 6 (2010): 2666-2670

Cited by18WOSBibtex

Discovery of pyrazolyl propionyl cyclohexenamide derivatives as full agonists for the high affinity niacin receptor GPR109A

Fa-Xiang Ding,Hong C Shen,Larrisa C Wilsie,Mihajlo L Krsmanovic,Andrew K Taggart,Ning Ren,Tian-Quan Cai,Junying Wang,Xinchun Tong,Tom G Holt,Qing Chen,M Gerard Waters

Bioorganic & Medicinal Chemistry Letters, no. 11 (2010): 3372-3375

WOSEIBibtex

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