Structural Biology and Translational Cancer Research
1. Structural Basis of Transmembrane Signaling
Our research is dedicated to uncovering the biochemical and structural intricacies of cross-membrane signaling, with a primary focus on 7-transmembrane G-protein-coupled receptors (GPCRs) and single-pass transmembrane receptors. In the realm of GPCRs, we strive to elucidate the activation mechanisms of both GPCRs and G-proteins, which are pivotal in biological signaling. To explore these molecular intricacies, we employ advanced cryo-electron microscopy (Cryo-EM) techniques. Our research also extends to investigating the structural basis of single-pass transmembrane receptors, aiming to provide a comprehensive understanding of transmembrane signaling processes.
2. Tumor Metastasis, Cancer Immunotherapy, and Drug Development
Tumor metastasis, the leading cause of cancer-related deaths, is a primary focus of our research. We delve into the mechanisms underlying tumor cell migration and invasion, identifying key proteins that drive these processes. By targeting these proteins for drug development, we aim to create effective treatments to curb tumor metastasis. Additionally, our research explores the roles of dendritic cells in cancer immunotherapy, contributing to the development of new cancer treatment approaches.