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The main goal of our research is to identify molecular mechanisms that control cellular plasticity and suppress tumour growth. Cells are able to change their characteristics and cell fate in response to external signals. This ability to change – cellular plasticity – underlies cancer initiation, metastasis and resistance to therapy. We are particularly interested in ‘guardians’ of plasticity in epithelial cells, from which over 80% of human tumours originate. We have a long-standing interest in the tumour suppressor p53 and the ASPP family of proteins (Apoptosis-Stimulating Protein of p53; Ankyrin repeats, SH3 domain and Proline rich sequence containing proteins), which have several roles including regulation of p53.
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论文共 213 篇作者统计合作学者相似作者
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Jingyi Ma,Khatoun Al Moussawi,Hantao Lou, Hok Fung Chan,Yihua Wang, Joseph Chadwick,Chansavath Phetsouphanh,Elizabeth A Slee, Shan Zhong,Thomas M Leissing,Andrew Roth,Xiao Qin,
Proceedings of the National Academy of Sciences of the United States of Americano. 10 (2024): e2309957121-e2309957121
Hannah S. Fuchs, Sabrina A. James,Thomas M. Carroll, Phil F. Xie, Joseph A. Chadwick, Duncan Parkes,Simon R. Lord, Lucinda Griffiths,Tim Underwood,Ioannis Karydis,Russell T. Petty,Benjamin Schuster-Böckler,
Cancer Researchno. 7_Supplement (2024)
James H. Schofield,Joseph Longo,Ryan D. Sheldon, Emma Albano,Abigail E. Ellis,Mark A. Hawk,Sean Murphy, Loan Duong,Sharif Rahmy,Xin Lu,Russell G. Jones,Zachary T. Schafer
Phil Xie, Masato Innoue,Paulina Siejka-Zielińska, Robert Amess, Jaeho Chang,Sam Wilding,Gareth Griffiths,Mark R. Middleton,Richard P. Owen,Chunxiao Song,Xin Lu, Benjamin Schuster-Boeckler
Cancer Researchno. 6_Supplement (2024): 2489-2489
Phil F. Xie, Jaeho Chang, Paulina Siejka-Zielinska, Masato Inoue, Magdalena Drozdz, Joseph A. Chadwick,Thomas M. Carroll, Richard P. Owen,Michael J. White, Joseph Kaplinsky, Robert Amess, Mark Middleton,
CANCER RESEARCHno. 8 (2023)
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Dedrick Kok Hong Chan, Amit Kumar Mandal,Scott D. Collins, Yi Zhou,Richard Owen, James Bundred,Jacob Househam,Trevor A. Graham,Xin Lü,Simon Buczacki
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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Cancer communications (London, England)no. 4 (2023): 499-503
Matthew Stower,Felix Zhou, Holly Hathrell, Jason Yeung,Shifaan Thowfeequ,Jonathan Godwin,Falk Schneider,Christoffer Lagerholm,Marco Fritzsche, Jeyan Thiyagalingam,Xin Lu, Jens Rittscher,
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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