基本信息
浏览量:25
职业迁徙
个人简介
Xiaoyin was awarded the Kavli Institute Award for Distinguished Research in Neuroscience for his PhD thesis work. He received a Discovery award from the Department of Defense Peer Reviewed Medical Research Program. His work in developing BARseq was featured by the NIH Director’s Blog, BRAIN Initiative Alliance, and various news media including Nature, Spectrum, Technology Networks, etc.
Research Interests
Xiaoyin is interested in understanding the wiring logic of neuronal types from a developmental and evolutionary perspective. To achieve this goal, his team is developing in situ sequencing-based tools that can interrogate various neuronal properties, such as gene expression and connectivity, with unprecedented throughput. These new tools will allow his team to interrogate the wiring among the basic units of a circuit, i.e. cell types, at an unprecedented scale, across the whole brain and across many individuals. Xiaoyin hopes that this systemic approach will not only reveal the basic organization of the normal brain with exquisite details, but also provides a path for discovering and understanding cellular and wiring defects in neuropsychiatric and neurodevelopmental diseases.
Expertise
In situ sequencing
Neuroanatomy
Spatial transcriptomics
Research Programs
Cell types
Barcoded connectomics
Research Interests
Xiaoyin is interested in understanding the wiring logic of neuronal types from a developmental and evolutionary perspective. To achieve this goal, his team is developing in situ sequencing-based tools that can interrogate various neuronal properties, such as gene expression and connectivity, with unprecedented throughput. These new tools will allow his team to interrogate the wiring among the basic units of a circuit, i.e. cell types, at an unprecedented scale, across the whole brain and across many individuals. Xiaoyin hopes that this systemic approach will not only reveal the basic organization of the normal brain with exquisite details, but also provides a path for discovering and understanding cellular and wiring defects in neuropsychiatric and neurodevelopmental diseases.
Expertise
In situ sequencing
Neuroanatomy
Spatial transcriptomics
Research Programs
Cell types
Barcoded connectomics
研究兴趣
论文共 24 篇作者统计合作学者相似作者
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Xiaoyin Chen, Stephan Fischer, Mara C P Rue, Aixin Zhang,Didhiti Mukherjee,Patrick O Kanold,Jesse Gillis,Anthony M Zador
Naturepp.1-10, (2024)
Cold Spring Harbor perspectives in biology (2024)
Daniel R. Goodwin, Alex Vaughan, Daniel Leible,Shahar Alon,Gilbert L. Henry,Anne Cheng,Xiaoyin Chen,Ruihan Zhang,Andrew G. Xue,Asmamaw T. Wassie,Anubhav Sinha,Yosuke Bando,
biorxiv(2022)
bioRxiv (Cold Spring Harbor Laboratory) (2022)
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Yushu Chen,Xiaoyin Chen, Batuhan Baserdem,Huiqing Zhan,Yan Li, Martin B. Davis,Justus M. Kebschull,Anthony M. Zador,Alexei A. Koulakov,Dinu F. Albeanu
biorxiv(2021)
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