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Our lab studies two fundamental aspects of biology that have broad implications for human health. The first research direction examines how cells faithfully duplicate their genomes and repair DNA lesions arising from endogenous and exogenous sources. The second direction focuses on how a protein modifier called SUMO mediates signal transduction, directs the DNA stress response, and dynamically regulates the functions of many proteins. We have implemented a versatile combination of molecular, genetic, biochemical, cell biological, and genomic/proteomic approaches toward answering these questions. Our current work aims to elucidate new underlying principles of the above processes, and reveal how they are integrated with other cellular functions to achieve cell proliferation under various conditions.
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论文共 87 篇作者统计合作学者相似作者
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Rongwei Zhao, Meng Xu,Anne R Wondisford,Rachel M Lackner,Jayme Salsman,Graham Dellaire,David M Chenoweth, Roderick J O'Sullivan,Xiaolan Zhao,Huaiying Zhang
bioRxiv : the preprint server for biology (2024)
bioRxiv : the preprint server for biology (2024)
Nature Structural & Molecular Biologyno. 6 (2023): 724-734
Shibai Li,You Yu, Jian Zheng, Victoria Miller- Browne,Zheng Ser,Huihui Kuang,Dinshaw J. Patel,Xiaolan Zhao
Proceedings of the National Academy of Sciences of the United States of Americano. 45 (2023): e2310924120-e2310924120
The Journal of biological chemistryno. 11 (2023): 105288-105288
biorxiv(2022)
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