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个人简介
Dr. Xiaobo Mao focuses on protein aggregation and prion-like spreading that drive the pathogenesis in neurodegenerative disorders, including Alzheimer's disease and Lewy Body Dementia. He pioneered the role of the receptors of prion-like proteins (tau and α-synuclein), including lymphocyte-activation gene 3 (LAG3), amyloid-β precursor-like protein 1 (APLP1), and neurexins, in mediating prion-like proteins cell-to-cell transmission and neuroinflammation. He and his collaborators identified the importance of the C-terminus of α-synuclein and serine129 phosphorylated α-synuclein binding to its receptors (LAG3 and APLP1), and the complex of APLP1-LAG3, exacerbating pathology spread and neurodegeneration. He co-discovered the targets of poly (ADP-ribose) polymerase (PARP) and PAR polymer facilitating prion-like protein spreading and neurodegeneration. He is also determining the role of pathogenic α-synuclein with different aggregation confirmation (strains) driving disease-specific α-synucleinopathies, including the underlying mechanism induced by environmental factors, and the association with clinical features.
研究兴趣
论文共 94 篇作者统计合作学者相似作者
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JOURNAL OF MEDICAL VIROLOGYno. 1 (2024): e29349-e29349
NANO TODAY (2024): 102142
Chan Chen, Ramhari Kumbhar,Hu Wang, Xiuli Yang,Kundlik Gadhave, Cyrus Rastegar,Yasuyoshi Kimura, Adam Behensky, Sumasri Kotha, Grace Kuo, Sruthi Katakam, Deok Jeong,
Advanced science (Weinheim, Baden-Wurttemberg, Germany)no. 16 (2024): e2303775-e2303775
crossref(2024)
Haiqing Chang,Erya Chen, Yi Hu,Lining Wu,Liyun Deng,Shixin Ye-Lehmann,Xiaobo Mao,Tao Zhu,Jin Liu,Chan Chen
ADVANCED SCIENCEno. 10 (2024): e2305554-e2305554
Hanseok Ko,Ted M Dawson,Bo Am Seo,Seung-Hwan Kwon,Donghoon Kim, Han-Byeol Kim,Shi-Xun Ma,Kundlik Gadhave, Noelle Burgess,Xiaobo Mao,Liana S Rosenthal,Javier Redding-Ochoa,
biorxiv(2024)
Phenotyping of Human iPSC-derived Neuronspp.73-96, (2023)
Signal Transduction and Targeted Therapyno. 1 (2023): 1-15
ACS SUSTAINABLE CHEMISTRY & ENGINEERINGno. 10 (2023): 4237-4247
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