基本信息
浏览量:0
职业迁徙
个人简介
Research interests
The Zheng Lab is interested in understanding:i)basic signaling mechanisms underlying cardiovascular development and diseases; and ii) the role of endothelium in organ development and regeneration.
The precisely regulated development and function of cardiovascular system is essential for the normal function of every other organ. The endothelium is also believed to provide instructive roles for organ development and regeneration. The understanding of how blood vessels form and maintain, and how endothelial cells interact with other cell types within organ systems is critical for designing treatments of many diseases, eg. from cardiovascular diseases, diabetes, cancer to dementia.
One of currently focused vascular diseases in Zheng Lab is cerebral cavernous malformation (CCM). CCMs are sporadic or inherited vascular malformations in the brain, which can lead to stroke. CCMs affects 0.1~0.5% people in the human population, yet the effective drug treatment is lacking. Mutations in three genes, CCM1, CCM2 and CCM3, have been identified as causing human CCM disease. The lab is currently using genetically engineered mouse model to mimic these human mutations and investigates how these genes control blood vessel formation and how their loss of function leads to vessel malformation. This research should lead to the identification of therapeutic targets for CCM and related vascular diseases.
The Zheng Lab is interested in understanding:i)basic signaling mechanisms underlying cardiovascular development and diseases; and ii) the role of endothelium in organ development and regeneration.
The precisely regulated development and function of cardiovascular system is essential for the normal function of every other organ. The endothelium is also believed to provide instructive roles for organ development and regeneration. The understanding of how blood vessels form and maintain, and how endothelial cells interact with other cell types within organ systems is critical for designing treatments of many diseases, eg. from cardiovascular diseases, diabetes, cancer to dementia.
One of currently focused vascular diseases in Zheng Lab is cerebral cavernous malformation (CCM). CCMs are sporadic or inherited vascular malformations in the brain, which can lead to stroke. CCMs affects 0.1~0.5% people in the human population, yet the effective drug treatment is lacking. Mutations in three genes, CCM1, CCM2 and CCM3, have been identified as causing human CCM disease. The lab is currently using genetically engineered mouse model to mimic these human mutations and investigates how these genes control blood vessel formation and how their loss of function leads to vessel malformation. This research should lead to the identification of therapeutic targets for CCM and related vascular diseases.
研究兴趣
论文共 57 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Shi-Ting Wu, Yu Feng,Renhua Song, Yanmiao Qi,Lin Li, Dongbo Lu,Yixuan Wang, Wenrun Wu,Angela Morgan,Xiaohong Wang,Yin Xia,Renjing Liu,
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2024)
Yixuan Wang, Baotao Ma, Youli Jian,Shi-Ting Wu,Alex Wong,Justin Wong,Edward M. Bonder,Xiangjian Zheng
FEBS JOURNALno. 5 (2024): 1008-1026
Biochimica et Biophysica Acta (BBA) - Molecular Cell Researchno. 6 (2023): 119488-119488
引用0浏览0WOS引用
0
0
Rongjie Ji,Jiayuan Chen, Yuyang Xie, Xudan Dou, Bo Qing,Zhiheng Liu,Yumei Lu,Lin Dang,Xu Zhu,Ying Sun,Xiangjian Zheng,Lirong Zhang,
JACC: Basic to Translational Scienceno. 2 (2023): 203-219
Zifeng Dai,Jingwei Li,Ying Li,Rui Wang,Huili Yan, Ziyu Xiong,Shiting Wu,Xi Yang, Dongbo Lu,Dongdong Zhang,Guofu Li, Yuwen Wang,
iScienceno. 12 (2022): 105642-105642
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn