基本信息
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职业迁徙
个人简介
My research is focused on computational biology and bioinformatics, with an emphasis on computational integrative genomics. Throughout my career, I put great value in identifying cutting-edge challenges, formulating novel computational problems, and develop innovative solutions. Below are the current foci of my research:
• Precision Medicine is the use of a patient’s genomic information to offer more precise and targeted treatment. Towards this goal, we have two specific aims: (1) working with clinicians to collect and analyze patient-specific genomics data, and (2) integrating different genomics datasets from the vast public repositories to extract useful information in support of (1). For example, over the past year we have been working on non-invasive methods of cancer diagnosis and monitoring based on “liquid biopsy”: the detection of circulating free DNA (cfDNA) released by tumors into the blood.
• Big Biodata Analysis has been a focus of our lab for more than a decade. In fact, the “big data” challenge of biology is more a “complex data” challenge, since even petabytes of many NGS datasets can be significantly compressed in size through preprocessing, but not in its biological complexity and platform heterogeneity. We have developed a series of methods to address this challenge. Our efforts include both horizontal integration (combining datasets of the same type, such as hundreds or even thousands of gene expression datasets) and vertical integration (combining datasets of different types, such as Hi-C, epigenomic, expression, and text data).
Academic Appointment, Affiliation, and Employment History
Professor, University of Southern California, 2012-
Associate Professor, University of Southern California, 2008-2012
Assistant Professor, University of Southern California, 2003-2008
Honors and Awards
NSF CAREER Award, 2008-2013
Sloan Research Fellowship Recipient, 2006-2008
研究兴趣
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Genome Biologyno. 1 (2017): 145-22
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