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The main goal of our research is to identify molecular mechanisms that control cellular plasticity and suppress tumour growth. Cells are able to change their characteristics and cell fate in response to external signals. This ability to change – cellular plasticity – underlies cancer initiation, metastasis and resistance to therapy. We are particularly interested in ‘guardians’ of plasticity in epithelial cells, from which over 80% of human tumours originate. We have a long-standing interest in the tumour suppressor p53 and the ASPP family of proteins (Apoptosis-Stimulating Protein of p53; Ankyrin repeats, SH3 domain and Proline rich sequence containing proteins), which have several roles including regulation of p53.
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LWTpp.116211, (2024)
CANCER COMMUNICATIONSno. 4 (2024): 499-503
Cell Reports Methodspp.100778-100778, (2024)
Food Chemistry (2024): 139651-139651
Jingyi Ma,Khatoun Al Moussawi,Hantao Lou, Hok Fung Chan,Yihua Wang, Joseph Chadwick,Chansavath Phetsouphanh,Elizabeth A. Slee, Shan Zhong,Thomas M. Leissing,Andrew Roth,Xiao Qin,
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICAno. 10 (2024): e2309957121-e2309957121
Hannah S. Fuchs, Sabrina A. James,Thomas M. Carroll, Phil F. Xie, Joseph A. Chadwick, Duncan Parkes,Simon R. Lord, Lucinda Griffiths,Tim Underwood,Ioannis Karydis,Russell T. Petty,Benjamin Schuster-Böckler,
Cancer Researchno. 7_Supplement (2024)
EClinicalMedicine (2024): 102629-102629
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