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To sustain life in different environments cells and organisms must adjust to different conditions and external cues. In contrast to immediate and mostly transient responses to short-term stimuli, processes of long-term adaptation require lasting changes in gene expression patterns. Such epigenetic changes are controlled on the level of chromatin, the packaging form of eukaryotic genomes. Here, different DNA and histone modifications are associated with distinct functional states of chromatin.
Overall, our research aims to gain detailed, fundamental understanding of the processes that read and translate patterns of chromatin marks for mediating biological outcomes. Currently, we are tackling two main questions. A) How do histone modifications in conjunction with DNA methylation establish seemingly stable chromatin structures in response to internal and external cues? B) How do small cellular metabolites and signaling molecules tune the readout of chromatin marks? To address these problems we are constantly expanding our highly interdisciplinary approaches. These include advancing technologies for establishing and analyzing complex chromatin systems in vitro (biochemistry and biophysics), molecular and cellular biology for studying essential chromatin components and global analysis of modules of epigenetic regulation.
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论文共 87 篇作者统计合作学者相似作者
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Tina Ukmar-Godec, Maria- Sol Cima-Omori,Zhadyra Yerkesh, Karthik Eswara,Taekyung Yu, Reshma Ramesh,Gwladys Riviere,Alain Ibanez de Opakua,Wolfgang Fischle,Markus Zweckstetter
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICAno. 50 (2023): e2308858120-e2308858120
Scientific Reportsno. 1 (2023): 1-12
ACS CENTRAL SCIENCEno. 2 (2022): 146-149
Protein Interactionspp.213-270, (2022)
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Science Advancesno. 34 (2022)
Deepanwita Sengupta,Liyong Zeng,Yumei Li,Simone Hausmann,Debopam Ghosh,Gang Yuan, Thuyen N Nguyen,Ruitu Lyu, Marcello Caporicci,Ana Morales Benitez,Garry L Coles,Vladlena Kharchenko,
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D-Core
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