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The Merrick laboratory seeks to identify all of the eukaryotic translation initiation factors and determine their sequential utilization in the initiation pathway. A secondary goal is to characterize how the initiation pathway is regulated and the different consequences depending on the exact point of regulation.
Current research is focusing on two major aspects of translation initiation, cap-dependent and cap-independent (or internal) initiation. Although much of the gross work has been determined using hemoglobin mRNA as a model mRNA, it has become clear that other elements influence both the regulation and mechanism of translation initiation in mammalian systems. Within the realm of cap-dependent translation, we are examining the influence of individual initiation factors on both overall affect on translation initiation and the affect of increased or decreased levels of initiation factors on start site selection in mRNAs containing in frame start sites which yield two proteins, one with a slightly longer N-terminal region than the other.
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Elsevier eBookspp.676-688, (2023)
R. Anderson, A. Agarwal,A. Ghosh, B. -J Guan, J. Casteel, N. Dvorina, W. M. Baldwin III, R. Mazumder,T. Y. Nazarko,W. C. Merrick,D. A. Buchner,M. Hatzoglou,
Cell reportsno. 8 (2020): 2481-2488.e5
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