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职业迁徙
个人简介
After 25 years of theoretical work in statistical mechanics, focusing on structure and phase transitions involving increasingly complex fluids – e.g., liquid crystals, self-assembling amphiphilic molecules, polymer solutions, and colloidal suspensions – I became seduced by viruses around 20 years ago and have been working ever since on trying to understand how they “work”. Collaborating with Avi Ben-Shaul on theory predicting high pressures in DNA viruses and various aspects of the self-assembly of RNA viruses, I started a lab with my colleague Chuck Knobler to carry out experiments on a broad range of physical aspects of viruses. We performed the first measurement of the pressure (~50 atm) in a DNA virus, and started taking simple RNA viruses apart and trying to put them back together again. We also made the first structure determinations of RNA viral genomes in their native state in solution, using synchrotron small-angle X-ray scattering, fluorescence correlation spectroscopy, and cryo-electron microscopy. Over the past 10 years we have included plant, insect, and mammalian viruses in our menagerie of RNA genome viruses, and have moved from exclusively in vitro work (purified viral components in test tubes) to studying how these viruses work in host cells. We have also begun to collaborate with pharmaceutical and biotech companies, and with medical research teams, on using our in vitro self-assembled virus-like particles containing therapeutic mRNA for gene and vaccine delivery purposes.
研究兴趣
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J. F. Torres-Salgado, M. V. Villagrana-Escareño, A. L. Duran-Meza, X. F. Segovia-Gonzalez, R. D. Cadena-Nava,W. M. Gelbart, C. M. Knobler, J. Ruiz-García
The European physical journal. E, Soft matterno. 12 (2023): 1-10
Biophysical journalno. 17 (2023): 3469-3475
Springer series in biophysicspp.57-70, (2023)
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K. J. Winchell,Patrick Y. Yee,Yolanda L. Li, Alexander F. Simafranca, Julia Chang,Christian Beren, Xinyu Liu, Diego Garcia Vidales,Robert J. Thompson,Charlene Z. Salamat, Quynh M. Duong,Robert S. Jordan,
MACROMOLECULESno. 8 (2023): 3160-3170
Rees F Garmann,Aaron M Goldfain,Cheylene R Tanimoto,Christian E Beren, Fernando F Vasquez, Daniel A Villarreal,Charles M Knobler,William M Gelbart,Vinothan N Manoharan
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