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Current research is focused entirely on pathophysiology and drug discovery for sickle cell disease, as well as monitoring ex-vivo sickling in sickle cell patients on drug trials, gene therapy trials, and natural history studies in collaboration with NHLBI and NIAID hematologists. A highly-sensitive, pathophysiologically-relevant and high throughput assays have been developed to screen compounds for ant-sickling activity. The assays use laser photolysis or nitrogen deoxygenation to induce sickling and automated image analysis to detect the formation of sickle fibers in individual red cells. As a strategy for the most rapid path to bringing a drug to market, the first phase of the screen is to test all U.S. Food and Drug Administration-approved drugs.
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Anna Conrey,Ingrid Frey,Nancy Asomaning, Ruth Pierre Charles,Dina Parekh,Julia Xu,Kang Le, Britney Kruah,Quan Li,Emily Dunkelberger,Troy Cellmer, Amber M Yates,
Blood (2023): 273
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BLOODno. Supplement 1 (2023): 2485-2485
FRONTIERS IN MOLECULAR BIOSCIENCES (2022): 1062346
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