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个人简介
William ‘Bill’ Richardson studies the development and function of cells called oligodendrocytes in the central nervous system. Oligodendrocytes produce myelin to insulate nerve axons, allowing action potentials (electrical impulses) to travel 10–100 times faster through the brain and spinal cord than would otherwise be possible.
Bill showed that, in the foetus, oligodendrocytes develop from the same stem cells as motor neurons, which control muscle contractions. This suggests that oligodendrocytes might have co-evolved with motor neurons to facilitate rapid movement — escape from predators, for example. However, during subsequent evolution, oligodendrocytes have been co-opted into many neural circuits in addition to those involved in motor control, dramatically increasing the brain's computational power.
Recently, Bill showed that oligodendrocytes continue to form throughout young adulthood, when they are used to insulate circuits that are newly activated while learning new skills such as juggling, playing the piano or learning a second language. He has received several honours for his work, including election as a Fellow of the Academy of Medical Sciences.
研究兴趣
论文共 256 篇作者统计合作学者相似作者
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Jordan L Wright, Yi Jiang, Stuart G Nayar,Pedro Cutillas,Vinothini Rajeeve,Huiliang Li,William D Richardson
biorxiv(2024)
Research Square (Research Square) (2023)
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bioRxiv (Cold Spring Harbor Laboratory) (2023)
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Takahiro Shimizu,Stuart G Nayar,Matthew Swire, Yi Jiang,Matthew Grist,David M Bannerman,Heidi Johansen-Berg, Katsutoshi Ogasawara,Koujiro Tohyama,William D Richardson
biorxiv(2023)
Yao Lulu Xing, Jasmine Poh, Bernard H A Chuang,Kaveh Moradi,Stanislaw Mitew,William D Richardson,Trevor J Kilpatrick,Yasuyuki Osanai,Tobias D Merson
Cell reports methodsno. 2 (2023): 100414
Takahiro Shimizu,Stuart G Nayar,Matthew Swire, Yi Jiang,Matthew Grist,Malte Kaller, Cassandra Sampaio Baptista,David M Bannerman,Heidi Johansen-Berg, Katsutoshi Ogasawara,Koujiro Tohyama,Huiliang Li,
Yao Lulu Xing, Jasmine Poh, Bernard H.A. Chuang,Kaveh Moradi,Stanislaw Mitew,William D. Richardson,Trevor J. Kilpatrick,Yasuyuki Osanai,Tobias D. Merson
crossref(2021)
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