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Rather than trying to model neuropsychiatric conditions directly, Dr. Carlezon’s lab uses multiple behavioral tests that capture their key signs, which in people are often overlapping (co-occurring). Ideally, the tests are sensitive to the same signs in animals that psychiatrists use to make diagnoses in people. We focus on the same types of endpoints in animals that can be collected and stored by smartphones, smartwatches, and activity trackers.
The work is performed in rats and mice using various strategies. For example, Dr. Carlezon and his staff might study how exposure to a particular type of stress affects motivated behavior, which is dysregulated in many types of neuropsychiatric disorders. They would then examine brain regions known to regulate motivation for the molecular changes that accompany observed behavioral changes.
To establish cause-effect relationships, genetic engineering techniques are used—for example, viral vectors and mutant mice—to reproduce individual molecular changes to see if they can cause the behavioral changes. Finally, this new information is used to design new medications that can block, reverse, or prevent the behavioral changes.
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biorxiv(2024)
biorxiv(2024)
Nature Communicationsno. 1 (2024): 1-20
BRAIN BEHAVIOR AND IMMUNITY (2024): 680-695
Scientific reportsno. 1 (2024): 8919-8919
Allison R. Foilb,Elisa M. Taylor-Yeremeeva,Emma L. Fritsch, Caitlin Ravichandran, Kimberly R. Lezak,Galen Missig,Kenneth M. McCullough,William A. Carlezon Jr.
NPP—Digital Psychiatry and Neuroscienceno. 1 (2024): 1-11
Scientific Reportsno. 1 (2024): 1-13
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