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Dr. Reeves’ and associates’ research focuses on the mechanisms of autoimmunity in systemic autoimmune diseases such as systemic lupus erythematosus (SLE), polymyositis, and Sjogren’s syndrome. They have found that the hydrocarbon oil pristane induces a lupus-like syndrome in normal mice characterized by the production of high levels of antinuclear antibodies specific for SLE as well as immune complex-mediated glomerulonephritis and arthritis. Using cytokine knockout mice, they have found that pristane-induced lupus is strongly dependent on IL-6 and interferon-g . The hypothesis that different manifestations of lupus (clinical and serological) result from the overproduction of these and other cytokines is being investigated in patients from the UF Lupus Research Center and in animal models in order to understand the interrelationships between genetic predisposition and environmental triggers of autoimmune disease.
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JOURNAL OF IMMUNOLOGYno. 2 (2024): 258-270
Leanne Dada, Loutfi Succari,Amy Y Vittor,William L Clapp,Haoyang Zhuang,Sami K Saikaly,Jena Auerbach,Shuhong Han,Borna Mehrad,Westley H Reeves
ARTHRITIS & RHEUMATOLOGYno. 1 (2021): 176-178
Lahita's Systemic Lupus Erythematosuspp.65-70, (2021)
Sjögren's Syndrome and Oral Healthpp.117-136, (2021)
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