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职业迁徙
个人简介
I am interested in the regulation of biological adhesion. Our major focus is on catch bonds, which are biological adhesive bonds that are activated by mechanical force. We study the biophysics of catch bonds that are involved in blood clotting and in bacterial infections. We hope that some of these projects will help us to better understand arterial thrombosis, with the long term role of developing new drugs that will prevent heart attacks and strokes without causing so much bleeding. In other projects, we hope to develop new antiadhesive therapies for urinary tract infections and endocarditis, hoping that these new approaches will not cause antibiotic resistance. Like a nanoscale locking seatbelt, catch bonds bind when needed but allow movement at other times, which makes them exciting new tools for adhesive technology that can be used in biosensing, molecular imaging, point-of-care diagnostics, targeted drug delivery, or minimally invasive microrobotics.
To study the biophysics of catch bonds, we apply and develop engineering tools such as single molecule biophysics instrumentation. We also study the role of catch bonds in cell adhesion by using integrative simulations to relate nanoscale to microscale behaviors, and by using site-directed mutagenesis to change molecular properties so we can see how the cell behavior changes. To develop new adhesive technology, we use the biophysics tools we have developed to predict and characterize desired properties for different applications. We also use protein engineering tools including RosettaDesign and directed evolution to engineer proteins with the desired properties.
To study the biophysics of catch bonds, we apply and develop engineering tools such as single molecule biophysics instrumentation. We also study the role of catch bonds in cell adhesion by using integrative simulations to relate nanoscale to microscale behaviors, and by using site-directed mutagenesis to change molecular properties so we can see how the cell behavior changes. To develop new adhesive technology, we use the biophysics tools we have developed to predict and characterize desired properties for different applications. We also use protein engineering tools including RosettaDesign and directed evolution to engineer proteins with the desired properties.
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Molly Y. Mollica, Emily Olszewski, Casey L. Kiyohara, Danafe D. Matusalem, Alexander R. Ochs,Princess I. Imoukhuede,Michael Regnier,Ken Yasuhara,Wendy E. Thomas,Alyssa C. Taylor
JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASMEno. 5 (2024): 1-38
PATHOGENSno. 7 (2023)
Biophysical reportsno. 2 (2021): 100031
Shivani Gupta Ludwig, Casey L. Kiyohara,Laura A. Carlucci,Dagmara Kisiela,Evgeni V. Sokurenko,Wendy Evelyn Thomas
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