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We are interested in molecular mechanisms underlying neural development, neuro-degeneration, and bone homeostasis. Although neural development, neurodegeneration, and bone homeostasis are three distinct events/processes, there are potential links among these processes. For examples, patients with neurodegenerative disorders, including Alzheimer’s disease (AD) and Parkinson’s disease (PD), frequently have non-cognitive/non-motor related defects. These non-typical symptoms occur earlier in AD/PD patients’ life, thus, they not only impact patients’ quality of life, but also could be predictor for disease progression. We have found that one of these non-typical defects is bone-degenerative-like phenotype. We therefore have invested significant efforts in understanding why and how the non-typical deficits (e.g., bone deficits) are associated with AD/PD. Technically, we have used a combination of biochemical (in vitro), cell biological (in culture), and genetic mutant animal models to address this issue.
研究兴趣
论文共 224 篇作者统计合作学者相似作者
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BIOLOGICAL PSYCHIATRYno. 12 (2023): 1071-1080
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biorxiv(2023)
Biological psychiatryno. 12 (2023): 1071-1080
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCESno. 9 (2023): 7809-7809
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Minghua Li, Jessica L Kinney,Yu-Qiu Jiang, Daniel K Lee, Qiwen Wu,Daehoon Lee,Wen-Cheng Xiong,Qian Sun
The Journal of neuroscience : the official journal of the Society for Neuroscienceno. 25 (2023): 4612-4624
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Yisheng Lu,Xiang-Dong Sun, Feng-Qing Hou,Lin -Lin Bi,Dong-Min Yin,Fang Liu, Yong -Jun Chen,Jonathan C. Bean,Hui-Feng Jiao,Xihui Liu,Bao-Ming Li,Wen-Cheng Xiong,
NEURONno. 10 (2023): 1684-1684
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