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The discovery of programmable DNA-targeting proteins has enabled editing of user-specified segments and base pairs in the genome of living cells. The derived genome engineering technologies have profound impact on genomic medicine. We discover, characterize, and engineer CRISPR-derived gene-editing agents for medical adaptation. We also aim to advancing lineage tracing and directed evolution platforms by CRISPR-based in situ DNA diversification.
The epigenome and epitranscriptome form one of the most intricate regulatory networks in human beings. These regulatory mechanisms function on top of the genetic codes and play central roles in cell fate specification. We dissect how epigenetic and epitranscriptomic modifications pivot cell fates at the molecular level. We actively work towards new biomarkers and drug targets based off in-house developed sequencing methods.
Peptides are potent protein-protein interaction modulators due to their extensive binding surface. Functionalized peptides (e.g., macrocyclization) are particularly promising because they can bind to target biomolecules with improved affinity and specificity and are less susceptible to protease degradation. Our lab constructs and screens genetically encoded, highly functionalized peptide libraries for high-throughput drug development.
The epigenome and epitranscriptome form one of the most intricate regulatory networks in human beings. These regulatory mechanisms function on top of the genetic codes and play central roles in cell fate specification. We dissect how epigenetic and epitranscriptomic modifications pivot cell fates at the molecular level. We actively work towards new biomarkers and drug targets based off in-house developed sequencing methods.
Peptides are potent protein-protein interaction modulators due to their extensive binding surface. Functionalized peptides (e.g., macrocyclization) are particularly promising because they can bind to target biomolecules with improved affinity and specificity and are less susceptible to protease degradation. Our lab constructs and screens genetically encoded, highly functionalized peptide libraries for high-throughput drug development.
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Nature Biotechnologypp.1-12, (2024)
Nature chemical biologyno. 1 (2024): 129-129
Yu Xiao, Yan-Ming Chen,Zhongyu Zou,Chang Ye,Xiaoyang Dou,Jinjun Wu,Chang Liu,Shun Liu, Hao Yan,Pingluan Wang, Tie-Bo Zeng, Qinzhe Liu,
Nature Methodsno. 2 (2024): 247-258
Alvin T. Huang,Weixin Tang
ACS CENTRAL SCIENCEno. 3 (2023): 346-348
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