基本信息
浏览量:158
职业迁徙
个人简介
Research Interests
Identifying and cataloging all gene sequences and their corresponding protein high-resolution static 3-dimensional structures is only a prelude to the real challenges of future biological inquiries. We need to understand the dynamic structural changes of isolated macromolecules undergoing biochemical reactions. We need to identify transient interactions between macromolecules. We need to decipher the cell circuitry and its detailed time-dependent responses to various stimuli. We need to decode intracellular and extracellular communication signals and the corresponding molecular-level responses of live cells, tissues and whole organs. Analytical tools will need to be developed in order to identify and measure these molecular conformations and interactions. High-sensitivity fluorescence methods will play a vital role in this endeavor because they offer many advantages for probing isolated molecules and molecules in live cells, tissues and organs. Fluorescence is non-invasive; it provides imaging and sectioning capabilities in three dimensions; it has high sensitivity, down to the single molecule level, and it allows the observation of molecular- and organelle-specific signals. Our group develops and applies ultrahigh-resolution, ultrahigh-sensitivity fluorescence imaging and spectroscopy tools to solving outstanding problems in biology.
研究兴趣
论文共 460 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Nature Communicationsno. 1 (2024): 1-16
Proceedings of SPIE--the International Society for Optical Engineering (2023)
Debjit Roy,Xavier Michalet, Kiran Bharadwaj,Evan W Miller,Yijie Wang,Arjun Deb,Michael A Wayne,Claudio Bruschini,Edoardo Charbon, Mahbanoo Vakili,Robert Gunsalus,Robert T Clubb,
The journal of physical chemistry lettersno. 10 (2023): 2702-2707
Ganesh Agam,Christian Gebhardt,Milana Popara, Rebecca Mächtel, Julian Folz,Benjamin Ambrose,Neharika Chamachi,Sang Yoon Chung,Timothy D. Craggs,Marijn de Boer,Dina Grohmann,Taekjip Ha,
Benjamin Ambrose, Victoria E. Hill,Robert A. Shaw,Tristan Johnston-Wood,Matthew Willmott, Callum Johnston, Rebecca Mächtel,Thorben Cordes,Eitan Lerner,J.G. Hill,Shimon Weiss,Timothy D. Craggs
Biophotonics Congress: Biomedical Optics 2022 (Translational, Microscopy, OCT, OTS, BRAIN) (2022)
引用0浏览0引用
0
0
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn