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个人简介
Dr. Zhang is a leader of precision oncology, using NFCR support since 2006 to characterize underlying genetic mechanisms responsible for cancer growth and progression. His research addresses the variability in cellular properties, within and across cancer types, which often leads to treatment resistance and poor survival in patients. For example, African-Americans diagnosed with lung cancer have higher incidences and lower survival rates than Caucasian Americans. Utilizing leading-edge genomic techniques, Dr. Zhang discovered that lung cancer in African-Americans expressed higher immunosuppressive components, permitting the lung cancer to escape attack by their immune system.
Dr. Zhang’s research has advanced our understanding of the role of genetic mutations in cancer progression and treatment: 1) lung cancer in African-Americans expresses a mutation in the TP53 tumor suppressor gene, leading to shorter survival times; 2) daily alcohol consumption causes DNA damage and changes in over 600 genes shown to be involved in cancer development; and 3) development of new computational methods utilizing artificial intelligence can predict the origin of cancers that have metastasized to the brain. Dr. Zhang’s precision oncology approach has the potential to improve outcomes for patients with non-Hodgkin’s lymphoma and leukemia, melanoma, and cancers of the lung, gastrointestinal tract, pancreas, ovary, uterus, brain and liver.
Dr. Zhang’s research has advanced our understanding of the role of genetic mutations in cancer progression and treatment: 1) lung cancer in African-Americans expresses a mutation in the TP53 tumor suppressor gene, leading to shorter survival times; 2) daily alcohol consumption causes DNA damage and changes in over 600 genes shown to be involved in cancer development; and 3) development of new computational methods utilizing artificial intelligence can predict the origin of cancers that have metastasized to the brain. Dr. Zhang’s precision oncology approach has the potential to improve outcomes for patients with non-Hodgkin’s lymphoma and leukemia, melanoma, and cancers of the lung, gastrointestinal tract, pancreas, ovary, uterus, brain and liver.
研究兴趣
论文共 1366 篇作者统计合作学者相似作者
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Peng Guo, Xiaojie Cao, Kangmin Chen, Zhihui Chen,Myung-Ki Cheoun,Yong-Beom Choi, Pak Chung Lam, Wenmin Deng,Jianmin Dong, Pengxiang Du,Xiaokai Du, Kangda Duan,
Atomic Data and Nuclear Data Tables (2024)
HLAno. 5 (2024): e15497-e15497
Xueqi Li, Chi Pan, Wenjun Ma,Ting Yang, Chong Wang, Weiwei Han,Wei Zhang,Hui Li,Zhongxia Li, Ting Zhao,Xiao-fei Guo,Duo Li
LWTpp.116211, (2024)
Xiaoling Wang,Wei Zhang,Siqi Zhao,Hao Yan,Zijuan Xin, Tiantian Cui,Ruge Zang, Lingping Zhao,Haiyang Wang,Junnian Zhou, Xuan Li,Wen Yue,
CELL PROLIFERATIONpp.e13614-e13614, (2024)
Cheng-Gong Luo,Jiao Zhang, Yun-Zhao An, Xuan Liu, Shuai-Jie Li,Wei Zhang,Kai Li, Xu Zhao,Dong-Bo Yuan, L. ing-Yue An,Wei Chen,Ye Tian,
BIOCELLno. 0 (2024): 1-10
Zhiying Xie,Chang Liu, Haiyan Yu,Zhihao Xie,Chengyue Sun,Ying Zhu, Xiaoyu Hu,Li Bai,Luhua Wei, Peng Sun,Yanyu Lu, Yunlong Lu,
Orphanet Journal of Rare Diseasesno. 1 (2024): 1-13
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