基本信息
浏览量:291
职业迁徙
个人简介
The major focus of research in my laboratory is aimed at understanding how APC and SCF activities contribute towards cell cycle regulation and subsequent tumor formation. More specifically, I am interested in elucidating the underlying mechanisms that define the oscillation of APC and SCF activity in different cell cycle phases. Currently I am pursuing the underlying mechanisms that timely regulate APC/Cdh1 activity in different cell cycle phases. Additionally, I am also interested in understanding whether other layers of crosstalk between the APC and SCF complex exist. Furthermore, I would like to identify novel downstream targets for both APC and SCF complexes, which will help pinpoint their functions in both cell cycle control and tumor formation. To this end, I have developed biochemical purification approaches that would allow me to identify novel downstream targets for APC/Cdh1 and SCF/Fbw7 complexes. In addition, I am also interested in defining the tumor suppressor function of Cdh1 utilizing conditional Cdh1 knockout mice. To achieve these goals, my lab will use multidisciplinary approaches including biochemical and genetic analysis. In the long term, I hope that a better understanding of the multilayer regulation of the delicate proteolysis pathways will lead us to the design of more efficient intervention strategies to combat cancer and other diseases.
研究兴趣
论文共 293 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Nature Communicationsno. 1 (2024): 1-16
Cancer Researchno. 6_Supplement (2024): 4728-4728
Shizhong Ke,Fabin Dang,Lin Wang,Jia-Yun Chen,Mandar T. Naik, Wenxue Li,Abhishek Thavamani,Nami Kim,Nandita M. Naik, Huaxiu Sui, Wei Tang,Chenxi Qiu,
Nature Communicationsno. 1 (2024): 1-21
Lang Bu, Zhengkun Zhang,Jianwen Chen,Yizeng Fan, Jinhe Guo,Yaqing Su, Huan Wang,Xiaomei Zhang,Xueji Wu,Qiwei Jiang,Bing Gao,Lei Wang,
GUT (2024)
Cong Jiang,Jing Liu, Shaohui He,Wei Xu,Runzhi Huang,Weijuan Pan, Xiaolong Li,Xiaoming Dai,Jianping Guo, Tao Zhang,Hiroyuki Inuzuka,Ping Wang,
Cell metabolismno. 12 (2023): 2183-2199.e7
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn