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职业迁徙
个人简介
My laboratory focuses on applying integrated structural and biochemical approaches to elucidate the molecular basis of protein-protein interactions and protein-ligand/drug interactions that are relevant to human health and diseases. Armed with such knowledge, we then apply chemical and pharmacological approaches to develop therapeutic innovations. Currently, we are studying the following proteins: Amyloid peptide-degrading proteases: Metalloproteases, insulin degrading enzyme (IDE) and presequence protease (PreP) degrade amyloid beta, a peptide vital for the progression of Alzheimer's disease.
Keywords
Protein structures and functions, Crystallography and CryoEM, Proteostasis, Diabetes, Bacterial pathogenesis
研究兴趣
论文共 166 篇作者统计合作学者相似作者
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Liang WG, J Wijaya,Hui Wei,Alex J. Noble,Jordan M. Mancl, Mo S,David E. Lee,John V. Lin King,Man Pan, Liu C, Carla M. Koehler,Minglei Zhao,
EMPIAR dataset (2022)
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Journal of molecular biologyno. 13 (2021): 166993-166993
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D-Core
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