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Dr. Wand's research focuses on exploring the relationships between static structure, structural dynamics and function in a range of protein systems. A key concept is the balance between changes in structure (enthalpy) and dynamics (entropy) is the binding of ligands. A range of systems involving protein-protein interactions as well as interactions with small ligands are being pursued. Through these studies a remarkably rich manifold of fast dynamical modes have been revealed and a surprising functional role for them discovered. These observations are being exploited to generate access to new avenues for drug design and engineering in a number of validated drug targets in cancer biology.
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Biophysical Reportsno. 1 (2023): 100098-100098
Duncan W S MacKenzie,Anna Schaefer, Julia Steckner, Christopher A Leo,Dalia Naser,Efrosini Artikis,Aron Broom,Travis Ko,Purnank Shah, Mikaela Q Ney, Elisa Tran,Martin T J Smith,
Annual review of biophysics (2021): 343-372
biorxiv(2021)
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