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Our research is aimed at understanding the development and function of blood platelets. These tiny, numerous cells initiate and co-ordinate blood clotting (i.e. hemostasis) at wound sites by adhering, aggregating and secreting a wide assortment of molecules. Platelets are also involved in the formation of arterial plaques and pathological clots such as the thrombi that cause heart attacks and strokes, major causes of mortality in the modern world. Many of our insights into the mechanisms of platelet development and function have come from studies of patients with inherited platelet disorders. Our particular interest is alpha granules, secretory vesicles that platelets use to transport and secrete several hundred different kinds of protein. We have identified several proteins and cellular pathways involved in the development of alpha granules in the cells that produce platelets, the bone marrow megakaryocytes.
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论文共 163 篇作者统计合作学者相似作者
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Raizl Gruda Sussman, Joy Mburu,MacGregor Steele, Annie Bang, Jeremy Friedman,Ran Goldman,Melanie Kirby,Margaret L. Rand,Victor S. Blanchette,Fred Pluthero,Suzan Williams,Walter H. Kahr
Research and Practice in Thrombosis and Haemostasispp.102374, (2024)
Raizl G Sussman, Joy Mburu,MacGregor Steele, Annie Bang,Jeremy Friedman,Ran Goldman,Melanie Kirby,Margaret L Rand,Victor S Blanchette,Fred G Pluthero,Suzan Williams,Walter H A Kahr
Research and practice in thrombosis and haemostasisno. 3 (2024): 102374-102374
Research and Practice in Thrombosis and Haemostasisno. 2 (2024): 102352-102352
Ratnashree Biswas,Emily K Boyd, Nathan Eaton, Agata Steenackers,Marie L Schulte,Friedrich Reusswig,Hongyin Yu, Caleb Drew,Walter H A Kahr,Qizhen Shi,Markus Plomann,Karin M Hoffmeister,
Richard J Y Liu, Yusef Al-Molieh,Shao Z Chen, Marko Drobac,Denisa Urban,Chang H Chen,Helen H Y Yao,Ryan S Q Geng,Ling Li,Fred G Pluthero,Samir Benlekbir,John L Rubinstein,
The Journal of biological chemistryno. 6 (2023): 104718-104718
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