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The research group, the Neuron-Glia Interactions in Retinal Diseases Section (NGIRDS), investigates the role of microglia, the resident immune cell of the retina, in normal physiological function and in the pathogenesis of retinal diseases. Of particular interest are retinal diseases in which age-related neuroinflammation features prominently, such as diabetic retinopathy and age-related macular degeneration (AMD), which are responsible for the majority of vision loss in the developed world. Key areas of focus are: 1) the role of microglia in the basic physiological function of the retina, and cell-cell interactions between microglia and other retinal cell types, 2) the aging phenotype of the retinal microglial cell, 3) the role of microglia in the pathogenesis of retinal disorders, and 4) translational research on microglial-based therapies in preclinical and proof-of-concept phase I/II clinical trials.
The laboratory has used a combination of ex vivo live-imaging techniques, in vitro studies, and animal models of disease to investigate the involvement of microglia in intercellular interactions with other retinal cell types under normal and pathological conditions. One key motivation is to understand how these cellular interactions undergo progressive change during senescence, resulting in age-related neuroinflammation that drive retinal disease pathogenesis. Dr. Wong is interested in discovering the molecular bases for these cellular interactions which allow the discovery of therapeutic targets directed at retinal microglia. The group is currently involved in a number of phase I/II trials using microglial inhibition as a treatment for diabetic retinopathy and retinal vein occlusions.
The laboratory has used a combination of ex vivo live-imaging techniques, in vitro studies, and animal models of disease to investigate the involvement of microglia in intercellular interactions with other retinal cell types under normal and pathological conditions. One key motivation is to understand how these cellular interactions undergo progressive change during senescence, resulting in age-related neuroinflammation that drive retinal disease pathogenesis. Dr. Wong is interested in discovering the molecular bases for these cellular interactions which allow the discovery of therapeutic targets directed at retinal microglia. The group is currently involved in a number of phase I/II trials using microglial inhibition as a treatment for diabetic retinopathy and retinal vein occlusions.
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论文共 250 篇作者统计合作学者相似作者
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Tiarnan D L Keenan,Clare Bailey,Maria Abraham,Christine Orndahl, Supriya Menezes,Sunil Bellur,Thilaka Arunachalam, Cathy Kangale-Whitney,Sowmya Srinivas,Ayesha Karamat, Muneeswar Nittala,Denise Cunningham,
JAMA ophthalmologyno. 4 (2024): 345-355
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JAMA OPHTHALMOLOGYno. 4 (2024): 345-355
Tiarnan Keenan, Clare Bailey,Sunil Bellur,Thilaka Arunachalam, Cathy Kangale-Whitney,Maria Abraham,Christine Orndahl,Supriya Menezes,Brett Jeffrey,Henry Wiley,Alisa Thavikulwat,Catherine Cukras,
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCEno. 8 (2023)
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INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCEno. 8 (2023)
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bioRxiv (Cold Spring Harbor Laboratory) (2023)
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INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCEno. 8 (2023)
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American Journal of Ophthalmology Case Reports (2022): 101647
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