Dr. Korn's reserach aims at the rational development of novel combination therapies for gastrointestinal cancer based on an improved understanding of cellular signal transduction pathways. His work is focused on targeting the EGF-receptor/RAS signal transduction pathways. Through collaborations with mathematicians and computer scientist his team has developed computerized models allowing for a systems-level description and simulation of signal transduction processes and functional endpoints (such as apoptosis and cell cycle) in cancer cells. This work has led to the discovery of new mechanisms of pathway cross-talk that led to the development of novel clinical trials that are currently ongoing.