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个人简介
Our team is helping lead the way toward a molecular basis for the cause, diagnosis, and treatment of Alzheimer’s disease. Alzheimer’s is a $250 billion a year epidemic that will confront virtually all families. In an early breakthrough study, we introduced the idea that neuron damage leading to AD is instigated by small toxic oligomers of the Aβ peptide. This new idea emerged from our discovery that oligomers are potent CNS toxins that rapidly destroy synaptic memory mechanisms. Our seminal paper (MP Lambert et al, PNAS 95:6448-6453, 1998) has been cited over 3500 times (Google Scholar; see e.g., the review in Nature by Schnabel “Little Proteins, Big Clues,” Nature, 475, S12-14, 2011). Since then, we have collaborated internationally to publish more than 100 papers (with over 16,000 citations) investigating the oligomer hypothesis and how it might lead to mechanism-based diagnostics and therapeutics. According to Eliezer Masliah, Director of Neuroscience for the National Institute on Aging, “Progressive accumulation of amyloid beta oligomers has been identified as one of the central toxic events in AD.” Soluble Aβ oligomers, rather than plaques, are now widely regarded as triggering the neuron damage that causes dementia. Toxic Aβ oligomers have provided, moreover, a structural archetype for cytotoxins germane to over two dozen diseases of protein misfolding (including diabetes, Parkinson’s, and prion diseases).
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论文共 279 篇作者统计合作学者相似作者
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ACTA NEUROPATHOLOGICA (2023)
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IBRO Neuroscience Reports (2023): S42-S42
Natalia Claudia Colettis, Maria-Victoria Oberholzer,Magalí Cecilia Cercato,Martín Habif,María Clara Sellés, Daniela Salas,Adriano Sebollela,William L. Klein,Alberto L. Epstein,Anna Salvetti,Sérgio T. Ferreira,Diana Jerusalinsky
Journal of Applied Cognitive Neuroscienceno. 1 (2023): e00344688-e00344688
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Psychopharmacologyno. 12 (2023): 2641-2655
Adriano Sebollela,Raquel Campos, Mariane Carraro,Nathalia Pinheiro, Andre Bitencour,Valentine Spagnol,Erika Cline,Navid Ayon, Jack Mcgee,Kirsten Viola,Steven Patrie,Neil Kelleher,
JOURNAL OF NEUROCHEMISTRY (2023): 104-104
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Maria Clara Selles,Juliana T S Fortuna,Magali C Cercato,Luis Eduardo Santos,Luciana Domett,Andre L B Bitencourt, Mariane Favero Carraro,Amanda S Souza,Helena Janickova, Caroline Vieira Azevedo, Henrique Correia Campos,Jorge M de Souza,
Dustin R Wakeman, Michael R Weed,Sylvia E Perez,Erika N Cline,Kirsten L Viola,Kyle C Wilcox, David S Moddrelle, Ernell Z Nisbett, Anish M Kurian, Amanda F Bell, Ricaldo Pike,Peer B Jacobson,
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