基本信息
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职业迁徙
个人简介
The current focus of the research program of the Jacobsen group is to apply different genetic tools and functional as well as molecular single cell analysis to unravel the dynamics of distinct stem and progenitor cells in unperturbed hematopoiesis as well as in response to distinct challenges, in mice as well as in normal human subjects. We also model the impact of recurrent genomic lesions at distinct stages of hematopoietic lineage commitment, to identify key cellular targets and molecular events in the transformation from normal to malignant hematopoiesis. In parallel we track the cellular fate and genomic evolution of clonal hematopoiesis in normal individuals as well as pre-leukemic and leukemic stem cells in patients during the natural course of hematopoietic malignancies and following treatment. Through these research directions we aim to identify novel therapeutic strategies towards regenerative hematopoiesis and targeting of leukemic stem cells.
研究兴趣
论文共 332 篇作者统计合作学者相似作者
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Pedro Luis Moura,Yasuhito Nannya, Affaf Aliouat, Isabel Juliana Hofman, Teresa Mortera Blanco,Tetsuichi Yoshizato,Ryunosuke Saiki,Masahiro M Nakagawa,Maria Creignou,Ann-Charlotte Björklund,Gunilla Walldin,Indira Barbosa,
Blood Neoplasiapp.100011, (2024)
Mariana Borsa, Sandrine Obba,Felix C. Richter,Hanlin Zhang,Thomas Riffelmacher,Joana Carrelha,Ghada Alsaleh,Sten Eirik W. Jacobsen, Anna Katharina Simon
AUTOPHAGYno. 1 (2024): 45-57
Pedro L. Moura,Teresa Mortera-Blanco, Isabel J. Hofman,Gabriele Todisco,Warren W. Kretzschmar,Ann-Charlotte Bjoerklund,Maria Creignou,Michael Hagemann-Jensen,Christoph Ziegenhain, David Cabrerizo Granados,Indira Barbosa,Gunilla Walldin,
CANCER RESEARCHno. 2 (2024): 211-225
Journal of clinical oncology : official journal of the American Society of Clinical Oncologypp.JCO2301159-JCO2301159, (2024)
Gabriele Todisco,Maria Creignou,Elsa Bernard,Ann-Charlotte Björklund,Pedro Luis Moura,Bianca Tesi,Teresa Mortera-Blanco,Birgitta Sander,Monika Jansson,Gunilla Walldin, Indira Barbosa, Susanne E. Reinsbach,
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Zenodo (CERN European Organization for Nuclear Research)no. 9 (2023): 1531-1541
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Gabriele Todisco,Maria Creignou,Elsa Bernard,Ann-Charlotte Björklund,Pedro Luis Moura,Bianca Tesi,Teresa Mortera-Blanco,Birgitta Sander,Monika Jansson,Gunilla Walldin, Indira Barbosa, Susanne E. Reinsbach,
crossref(2023)
Gabriele Todisco,Maria Creignou,Elsa Bernard,Ann-Charlotte Björklund,Pedro Luis Moura,Bianca Tesi,Teresa Mortera-Blanco,Birgitta Sander,Monika Jansson,Gunilla Walldin, Indira Barbosa, Susanne E. Reinsbach,
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Alba Rodriguez-Meira,Ruggiero Norfo, Sean Wen,Agathe L. Chédeville,Haseeb Rahman, Jennifer O’Sullivan,Guanlin Wang,Eleni Louka,Warren W. Kretzschmar,Aimee Paterson,Charlotte Brierley,Jean-Edouard Martin,
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