Dr. Freeman's primary interests are centered around precision medicine of brain-injury and stroke, and in particular hemorrhage stroke, and intraventricular drug discovery, translation, and application. Dr. Freeman was part of the international CLEAR III steering committee and pioneered several innovative brain-injection drug methodologies with global scientific collaborators. Dr. Freeman holds the academic rank of Professor of Neurology and Neurosurgery at Mayo Clinic, and has appointments within the Departments of Neurosurgery, Neurology, and Critical Care Medicine.

Dr. Freeman has more than 230 peer-reviewed National Library of Medicine publications, and has four textbooks, including one by Cambridge and another by Oxford on hospital neurology, critical care, and neurological emergencies. Dr. Freeman is the founding Neurosciences ICU medical director at Mayo Clinic in Florida, and one of the co-directors of the Mayo Clinic Comprehensive Stroke Center. Dr. Freeman is the Program Director for two separate neurocritical care fellowships one with the United Council of Neurological Subspecialties (UCNS) and other with the Society of Neurological Surgeons (SNS). He has obtained numerous honors and awards including the Mayo Clinic Distinguished Educator award in 2015, and the Mayo Clinic Enterprise Program Director award in 2016 and is among the most prolific educators in CPD (Continuous Professional Development) content creation and design in the neurosciences.

Dr. Freeman's other research interests include health economics and he Co-Chaired the national WorkForce Task Force for the American Academy of Neurology in 2012-2015 nationally. He is also interested in advancing population and individualized medicine using robotic telemedicine and mobile health Apps.