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The focus of research in the Hook Laboratory is to identify peptide and protease neurochemical mechanisms as new drug target strategies for brain disorders including neurological, neurodegenerative, and mental health diseases. The research addresses discovery of new drug strategies for Alzheimer’s and Huntington’s neurodegenerative diseases, traumatic brain injury (TBI), chronic pain, and mental health conditions of schizophrenia and bipolar disease. The neurochemical drug target strategies involve neurotransmitter profiling analyses by peptidomics and metabolomics mass spectrometry combined with proteomics, chemical biology of protease targets, genetics, via human brain focused investigations. Drug discovery combines evaluation of marine natural products with analyses of clinical drug molecules. This research addresses the unmet need for new therapeutic drugs to treat brain disorders
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论文共 181 篇作者统计合作学者相似作者
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Sonia Podvin,Jeffrey Jones,Austin Kang, Ryan Goodman, Patrick Reed, Christopher B. Lietz, Joshua Then,Kelly C. Lee,Lisa T. Eyler, Dilip V. Jeste, Fred H. Gage,Vivian Hook
Molecular Psychiatrypp.1-10, (2024)
Jehad Almaliti, Momen Alhindy,Michael C. Yoon,Vivian Hook,Tadeusz F. Molinski, Anthony J. O'Donoghue,William H. Gerwick
ACS OMEGAno. 3 (2024): 3997-4003
Journal of Huntington's diseaseno. 4 (2023): 315-333
JOURNAL OF ALZHEIMERS DISEASEno. 1 (2023): 33-46
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Journal of Alzheimer's disease : JADno. 1 (2023): 33-46
Ben Boyarko,Sonia Podvin,Barry Greenberg, Jeremiah D Momper,Yadong Huang,William H Gerwick, Anne G Bang,Luisa Quinti,Ana Griciuc,Doo Yeon Kim,Rudolph E Tanzi,Howard H Feldman,
Biochemistryno. 15 (2023): 2289-2300
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ACS omegano. 29 (2022): 25346-25352
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