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职业迁徙
个人简介
I am basic/translational research scientist and the overall goal of my research is to understand molecular mechanisms and signaling pathways that mediate lung inflammation and injury and develop novel therapeutic agents to ameliorate pulmonary leak, lung edema, and restore barrier integrity. Three major areas of focus are: (i) mechanisms of ROS production and role of ROS regulation of pro-inflammatory genes in lung disorders, (ii) Sphingolipids in lung pathologies and intracellular S1P as a co-epigenetic regulator of lung inflammation and injury, and (iii) Role of cardiolipin (CL) and CL remodeling enzyme, lysocardiolipin acyltransferase in development, progression and metastasis of non-small cell lung cancer. The underlying premise is that understanding basis of altered chromatin remodeling by ROS and S1P in different lung pathologies will help to identify signaling targets and develop new pharmacological approaches to restore lung function and integrity. Recently, my group has initiated new and exciting studies on S1P as a co-epigenetic regulator of chromatin remodeling and expression of pro-inflammatory genes in sepsis- and bacteria-mediated lung inflammation and injury. Our preliminary data show that in sepsis-induced lung injury, S1P generated by SphK1 regulated chromatin remodeling while in Pseudomonas aeruginosa infection of the mouse lung, nuclear SphK2 played an important role in H3 and H4 histone acetylation and chromatin remodeling.
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Tara Sudhadevi, Steven J Ackerman,Anjum Jafri,Prathima Basa,Alison W Ha,Viswanathan Natarajan,Anantha Harijith
American journal of physiology. Lung cellular and molecular physiologyno. 3 (2024): L377-L392
Zhenguo Zeng, Eltyeb Abdelwahid,Weiguo Chen,Christian Ascoli, Trinh Pham, Jeffrey R Jacobson,Steven M Dudek,Viswanathan Natarajan,C Marcelo Aldaz,Roberto F Machado, Sunit Singla
American journal of physiology. Lung cellular and molecular physiology (2024)
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PHYSIOLOGYno. S1 (2023)
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Indian journal of ophthalmologyno. 5 (2023): 2139-2142
Ramasamy Jagadeeswaran, Hanna Surawska,Soundararajan Krishnaswamy,Varalakshmi Janamanchi, A. Craig Mackinnon,Tanguy Y. Seiwert,Sivakumar Loganathan,Rajani Kanteti,Trevor Reichman,Vidya Nallasura,Stuart Schwartz,Leonardo Faoro,
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