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个人简介
Our group is involved with 4 research projects:
1. Mechanisms by which fatty acids acutely stimulate insulin secretion, and more precisely the role of the GPR40 receptor. Using GPR40 knock-out mice, we have shown that GPR40 mediates approximately 50% of the stimulatory effect of fatty acids on insulin secretion in vitro and in vivo, but is not implicated in their long-term, deleterious effects on beta-cell function. We are currently generating a mouse line with beta-cell specific deletion of GPR40.
2. We are studying the molecular mechanisms by which chronic fatty acids inhibit insulin gene expression. We have shown that this involves a blockade of the nuclear translocation of the transcription factor Pdx-1, as well as reduced expression of the transcription factor MafA. We are currently investigating the signaling pathways involved in palmitate inhibition of insulin gene expression.
3. We have established an in vivo model of nutrient excess by chronic perfusion in the rat. In collaboration with the group of Marc Prentki, we are now examining the effects of age and genetic predisposition on the development of diabetes in this model. Nous avons mis au point un modèle d’excès en nutriments chez le rat par perfusion chronique, et évaluons, en collaboration avec le groupe de Marc Prentki, les effets de l’âge et de la prédisposition génétique sur le développement du diabète.
4. In collaboration with the group of Richard Smith at the Pacific Northwest National Laboratories in Richmond, WA, we are carrying out a study which aims to perform proteomics and metabolomics profiling of isolated human islets and to determine if changes in these global profiles correlate with islet function in vitro and in vivo, to establish predictive criteria of islet function prior to transplantation.
研究兴趣
论文共 249 篇作者统计合作学者相似作者
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JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS (2023)
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DIABETESno. 7 (2023): S91-S119
Canadian Journal of Cardiologyno. 7 (2023): S126
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Canadian Journal of Cardiologyno. 7 (2023): S89-S89
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Julie Lacombe,Kevin Guo, Jessica Bonneau,Denis Faubert, Florian Gioanni,Alexis Vivoli, Sarah M Muir, Soraya Hezzaz,Vincent Poitout,Mathieu Ferron
Cell reportsno. 5 (2023): 112500-112500
biorxiv(2022)
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