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Retroviruses are associated with a wide range of clinical diseases, including leukemia, tumors, and acquired immunodeficiency syndrome. Human immunodeficiency virus (HIV) is an exceptionally deadly retrovirus that has caused more than 20 million deaths over the past two decades. Due to the emergence of resistant strains, it is unlikely that current drug strategies, which target individual proteins, will lead to a cure. There is a serious need for superior approaches: for example, targeting anti-viral drugs towards essential RNA-protein or protein-protein interactions. To this end, I am interested in studying the structural determinants of reverse transcription and gene translation in retroviruses like HIV, Human T-cell leukemia virus and Moloney murine leukemia virus (MLV). Although aspects of reverse transcription and gene translation have received considerable attention, understanding of RNA structures and events that promote or regulate these steps remain primitive.
Nuclear magnetic resonance (NMR) and other biophysical and biochemical methods are the principal tools used in my laboratory to study these relatively large RNA and protein molecules. The structure determination of large protein- RNA complexes by NMR is extremely challenging, but the potential payoff is high and should ultimately lead to detailed models of steps involved in retroviral replication.
Nuclear magnetic resonance (NMR) and other biophysical and biochemical methods are the principal tools used in my laboratory to study these relatively large RNA and protein molecules. The structure determination of large protein- RNA complexes by NMR is extremely challenging, but the potential payoff is high and should ultimately lead to detailed models of steps involved in retroviral replication.
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论文共 23 篇作者统计合作学者相似作者
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Raphael Haslecker,Vincent V. Pham,David Glänzer,Christoph Kreutz, Theodore Kwaku Dayie,Victoria M. D’Souza
Research squareno. 1 (2023): 8422-12
semanticscholar(2021)
biorxivpp.1-54, (2020)
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