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Dr. Chauhan has established a productive translational electrophysiology research program supported by the Heart and Stroke Foundation of Ontario and the Canadian Foundation for Innovation. The program is characterizing cardiac repolarization dynamics in patients with cardiomyopathy as it related to the pathogenesis of lethal ventricular tachyarrhythmias. Although experimental studies suggest that abnormal ventricular repolarization is responsible for ventricular arrhythmias and sudden death, the relevance of cardiac repolarization as a substrate for arrhythmogenesis in humans is less clear. His laboratory is characterizing the spatiotemporal distribution of ventricular repolarization in patients with cardiomyopathy and defining the dynamic range of repolarization in response to physiologic stress that can trigger ventricular arrhythmias. The experiments involve body surface and intracardiac recordings of repolarization under varying physiological conditions. Using linear and nonlinear dynamics, several aspects of cardiac repolarization are quantified including spatiotemporal heterogeneity, restitution, memory and alternans. The knowledge gained from these studies will provide better understanding of the pathogenesis of lethal ventricular arrhythmias in patients with heart disease which may lead to the development of novel antiarrhythmic therapies.
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The Canadian journal of cardiologyno. 10 (2023): 1421-1431
Canadian Journal of Cardiology (2023)
medrxiv(2023)
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Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology (2023)
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JAMA cardiologyno. 5 (2023): 475-483
JACC: Clinical Electrophysiologyno. 8 (2022): 1010-1020
Canadian Journal of Cardiologyno. 10 (2022): S147-S148
Mahmoud M. Bokhari,Shun Liao,Praloy Chakraborty, Gavin Jones,Michael H. Gollob,Zhaolei Zhang,Vijay S. Chauhan
Heart Rhythmno. 5 (2022): S286-S287
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