基本信息
浏览量:7
职业迁徙
个人简介
We investigate the interactions of metals in biological systems, with emphasis on nucleic acids. This interdisciplinary research area combines chemical biology, bioinorganic chemistry, and biophysical chemistry. Research topics include the roles of metal ions in catalytic RNAs (ribozymes) and platinum compounds as RNA crosslinking reagents for enhancing structure-function studies. We are particularly interested in understanding how metal compounds, including anticancer agents, interact with cellular RNAs; RNA is a fascinating biopolymer that plays many different roles in regulating biological processes. To advance this unexplored area, we are engaged in developing high-throughput and novel methods and reagents for measuring in-cell platinum adducts and their biological consequences. In recent work we have synthesized a suite of new Pt(II) compounds modified for click-chemistry that enable post-treatment detection, including imaging bound Pt in mammalian cell culture and enriching for Pt-bound targets for downstream analysis. Another current direction is to understand the surprising specificity of certain Pt compounds to influence the nucleolus, the site of ribosome biogenesis and 'Achilles heel' of a growing cell. Our laboratory team is interdisciplinary and inclusive, and we welcome a range of backgrounds including synthetic, biological, inorganic, and analytical chemistry.
研究兴趣
论文共 122 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Paul D. O'Dowd,Andres S. Guerrero, Katelyn R. Alley, Hannah C. Pigg, Fiona O'Neill, Justine Meiller, Chloe Hobbs,Daniel A. Rodrigues,Brendan Twamley, Finbarr O'Sullivan,Victoria J. Derose,Darren M. Griffith
ACS CHEMICAL BIOLOGYno. 4 (2024): 875-885
Andres S. Guerrero,Paul D. O'Dowd, Hannah C. Pigg, Katelyn R. Alley,Darren M. Griffith,Victoria J. Derose
RSC CHEMICAL BIOLOGYno. 10 (2023): 785-793
Hannah C Pigg,Matthew V Yglesias,Emily C Sutton,Christine E McDevitt, Michael Shaw,Victoria J DeRose
Comprehensive Coordination Chemistry IIIpp.968-993, (2021)
OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information) (2020)
引用0浏览0引用
0
0
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn