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The Carruthers lab seeks to understand survival strategies employed by microbial pathogens during infection. We use the protozoan Toxoplasma gondii(link is external) as a model pathogen because of its genetic and biochemical tractability, well-defined cellular structure, and the availability of excellent rodent models of disease. Toxoplasma replicates in a remarkable variety of cells and organs, causing encephalitis, pneumonia, myocarditis, ocular disease, and congenital birth defects during acute infection. While disease is seen in only a small fraction of the ~2 billion people infected worldwide, the diagnosis and treatment of toxoplasmosis are suboptimal and the disease remains a significant and neglected(link is external) public health problem. In people with healthy immune status, the parasite typically remains in a chronic, encysted state, but the infection can erupt when immune function is compromised such as individuals with HIV/AIDS, organ transplant recipients, or cancer patients undergoing chemotherapy.
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mBiono. 4 (2024): e0028324-e0028324
MSPHEREno. 1 (2024): e0059723-e0059723
Hargobinder Kaur,Einar Olafsson,Rebekah Guevara,Joshua Mayoral, Phyllis Hanson,Louis Weiss,Vernon Carruthers
Journal of Biological Chemistryno. 3 (2024)
bioRxiv : the preprint server for biology (2023)
PLOS PATHOGENSno. 5 (2023)
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Dana Aghabi,Megan Sloan, Grace Gill, Elena Hartmann,Olga Antipova,Zhicheng Dou,Alfredo J. Guerra,Vern B. Carruthers,Clare R. Harding
biorxiv(2023)
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